MedKoo Cat#: 556047 | Name: MRN73473
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRN73473, also known as Menin-MLL inhibitor 20, is an irreversible menin-MLL interaction inhibitor with antitumor activities. This compound was first reported in patent WO2020142557A1 (compound 6). This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

MRN73473
MRN73473
CAS#2448173-47-3

Theoretical Analysis

MedKoo Cat#: 556047

Name: MRN73473

CAS#: 2448173-47-3

Chemical Formula: C33H40N8O4

Exact Mass: 612.3173

Molecular Weight: 612.74

Elemental Analysis: C, 64.69; H, 6.58; N, 18.29; O, 10.44

Price and Availability

Size Price Availability Quantity
100mg USD 1,650.00 2 Weeks
200mg USD 2,650.00 2 Weeks
500mg USD 4,250.00 2 Weeks
1g USD 5,950.00 2 Weeks
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Synonym
Menin-MLL inhibitor 20; MRN73473; MRN-73473; MRN 73473;
IUPAC/Chemical Name
tert-butyl (R)-(1-((2-((4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)carbamoyl)pyridin-4-yl)methyl)piperidin-3-yl)carbamate
InChi Key
MPFHTFMFYAODPE-RUZDIDTESA-N
InChi Code
InChI=1S/C33H40N8O4/c1-33(2,3)45-32(43)38-25-5-4-12-40(20-25)19-22-10-11-34-28(17-22)31(42)37-24-8-6-23(7-9-24)27-18-26-29(39-27)35-21-36-30(26)41-13-15-44-16-14-41/h6-11,17-18,21,25H,4-5,12-16,19-20H2,1-3H3,(H,37,42)(H,38,43)(H,35,36,39)/t25-/m1/s1
SMILES Code
O=C(OC(C)(C)C)N[C@H]1CN(CC2=CC(C(NC3=CC=C(C4=CC5=C(N6CCOCC6)N=CN=C5N4)C=C3)=O)=NC=C2)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 612.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Dempke WCM, Desole M, Chiusolo P, Sica S, Schmidt-Hieber M. Targeting the undruggable: menin inhibitors ante portas. J Cancer Res Clin Oncol. 2023 Sep;149(11):9451-9459. doi: 10.1007/s00432-023-04752-9. Epub 2023 Apr 27. PMID: 37103568.