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MedKoo Cat#: 465707 | Name: SkQTR1 Br

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SkQTR1 Br is a class of mitochondria-targeted antioxidant. It exhibited pro-oxidant properties stimulating ROS production and a pronounced anti-inflammatory effect.

Chemical Structure

SkQTR1 Br
SkQTR1 Br
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465707

Name: SkQTR1 Br

CAS#: unknown

Chemical Formula: C44H55BrN2O5

Exact Mass: 770.3294

Molecular Weight: 771.84

Elemental Analysis: C, 68.47; H, 7.18; Br, 10.35; N, 3.63; O, 10.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SkQTR1 Br; SkQTR 1 Br; SkQTR-1 Br; SkQTR1 bromide; SkQTR 1 bromide; SkQTR-1 bromide;
IUPAC/Chemical Name
(Z)-N-(9-(2-(((10-(2,5-dihydroxy-3,4-dimethylphenyl)decyl)oxy)carbonyl)phenyl)-6-(ethylamino)-2,7-dimethyl-3H-xanthen-3-ylidene)ethanaminium bromide
InChi Key
CLSFCGLWMCHZOR-JTSVEUPUSA-N
InChi Code
InChI=1S/C44H54N2O5.BrH/c1-7-45-37-26-40-35(23-28(37)3)42(36-24-29(4)38(46-8-2)27-41(36)51-40)33-20-16-17-21-34(33)44(49)50-22-18-14-12-10-9-11-13-15-19-32-25-39(47)30(5)31(6)43(32)48;/h16-17,20-21,23-27,45,47-48H,7-15,18-19,22H2,1-6H3;1H/b46-38-;
SMILES Code
CC1=C(O)C=C(CCCCCCCCCCOC(C2=C(C(C(C=C(C)C(NCC)=C3)=C3O4)=C5C4=C/C(C(C)=C5)=[NH+]/CC)C=CC=C2)=O)C(O)=C1C.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 771.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Isaev NK, Stelmashook EV, Genrikhs EE, Korshunova GA, Sumbatyan NV, Kapkaeva MR, Skulachev VP. Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type. Rev Neurosci. 2016 Dec 1;27(8):849-855. doi: 10.1515/revneuro-2016-0036. PMID: 27559690. 2: Genrikhs EE, Stelmashook EV, Popova OV, Kapay NA, Korshunova GA, Sumbatyan NV, Skrebitsky VG, Skulachev VP, Isaev NK. Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid- β-induced impairment of long-term potentiation in rat hippocampal slices. J Drug Target. 2015 May;23(4):347-52. doi: 10.3109/1061186X.2014.997736. Epub 2015 Jan 14. PMID: 25585580.