MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 465705 | Name: SkQPalm Br

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SkQPalm Br is a class of mitochondria-targeted antioxidant. It exhibited pro-oxidant properties stimulating ROS production and a pronounced anti-inflammatory effect.

Chemical Structure

SkQPalm Br
SkQPalm Br
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465705

Name: SkQPalm Br

CAS#: unknown

Chemical Formula: C40H50BrNO8

Exact Mass: 751.2720

Molecular Weight: 752.74

Elemental Analysis: C, 63.83; H, 6.70; Br, 10.62; N, 1.86; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SkQPalm Br; SkQ Palm Br; SkQ-Palm Br; SkQPalm bromide; SkQPalm bromide; SkQPalm bromide;
IUPAC/Chemical Name
13-(2-((9-(2,5-dihydroxy-3,4-dimethylphenyl)nonyl)oxy)-2-oxoethyl)-2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium bromide
InChi Key
ZCMISCWZHRUPNA-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H49NO8.BrH/c1-25-26(2)39(44)28(20-33(25)42)14-12-10-8-7-9-11-13-19-49-37(43)23-31-29-15-16-34(45-3)40(48-6)32(29)24-41-18-17-27-21-35(46-4)36(47-5)22-30(27)38(31)41;/h15-16,20-22,24H,7-14,17-19,23H2,1-6H3,(H-,42,44);1H
SMILES Code
CC1=C(O)C=C(CCCCCCCCCOC(CC2=C3[N+](CCC4=CC(OC)=C(OC)C=C43)=CC5=C2C=CC(OC)=C5OC)=O)C(O)=C1C.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 752.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chernyak BV, Antonenko YN, Galimov ER, Domnina LV, Dugina VB, Zvyagilskaya RA, Ivanova OY, Izyumov DS, Lyamzaev KG, Pustovidko AV, Rokitskaya TI, Rogov AG, Severina II, Simonyan RA, Skulachev MV, Tashlitsky VN, Titova EV, Trendeleva TA, Shagieva GS. Novel mitochondria-targeted compounds composed of natural constituents: conjugates of plant alkaloids berberine and palmatine with plastoquinone. Biochemistry (Mosc). 2012 Sep;77(9):983-95. doi: 10.1134/S0006297912090040. PMID: 23157257. 2: Chernyak BV, Antonenko YN, Domnina LV, Ivanova OY, Lyamzaev KG, Pustovidko AV, Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, Zvyagilskaya RA. Novel penetrating cations for targeting mitochondria. Curr Pharm Des. 2013;19(15):2795-806. doi: 10.2174/1381612811319150015. PMID: 23092317. 3: Pustovidko AV, Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, Lyamzaev KG, Antonenko YN, Rogov AG, Zvyagilskaya RA, Skulachev VP, Chernyak BV. Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria. Mitochondrion. 2013 Sep;13(5):520-5. doi: 10.1016/j.mito.2012.09.006. Epub 2012 Sep 29. PMID: 23026390. 4: Lyamzaev KG, Pustovidko AV, Simonyan RA, Rokitskaya TI, Domnina LV, Ivanova OY, Severina II, Sumbatyan NV, Korshunova GA, Tashlitsky VN, Roginsky VA, Antonenko YN, Skulachev MV, Chernyak BV, Skulachev VP. Novel mitochondria- targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatine. Pharm Res. 2011 Nov;28(11):2883-95. doi: 10.1007/s11095-011-0504-8. Epub 2011 Jun 14. PMID: 21671134.