MedKoo Cat#: 577545 | Name: PS-519

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PS-519 is a human tissue plasminogen activator and proteasome inhibitor.

Chemical Structure

PS-519
PS-519
CAS#211866-70-5

Theoretical Analysis

MedKoo Cat#: 577545

Name: PS-519

CAS#: 211866-70-5

Chemical Formula: C12H19NO4

Exact Mass: 241.1314

Molecular Weight: 241.29

Elemental Analysis: C, 59.73; H, 7.94; N, 5.81; O, 26.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LDP-519; LDP 519; LDP519; MLN-519; MLN 519; MLN519; PS-519; PS 519; PS519
IUPAC/Chemical Name
(1S,2R,5R)-5-((1S)-1-Hydroxy-2-methyl-propyl)-2-propyl-7-oxa-4-azabicyclo(3.2.0)heptane-3,6-dione
InChi Key
KMXHEXRPYSXLRN-JDVQERKKSA-N
InChi Code
1S/C12H19NO4/c1-4-5-7-9-12(11(16)17-9,13-10(7)15)8(14)6(2)3/h6-9,14H,4-5H2,1-3H3,(H,13,15)/t7-,8+,9+,12-/m1/s1
SMILES Code
CCC[C@@H]1[C@@H]2OC(=O)[C@@]2(NC1=O)[C@@H](O)C(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 241.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhang L, Zhang ZG, Zhang RL, Lu M, Adams J, Elliott PJ, Chopp M. Postischemic (6-Hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia. Stroke. 2001 Dec 1;32(12):2926-31. doi: 10.1161/hs1201.100207. PMID: 11739997. 2. Vanderlugt CL, Rahbe SM, Elliott PJ, Dal Canto MC, Miller SD. Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519. J Autoimmun. 2000 May;14(3):205-11. doi: 10.1006/jaut.2000.0370. PMID: 10756082. 3. Shah IM, Lees KR, Pien CP, Elliott PJ. Early clinical experience with the novel proteasome inhibitor PS-519. Br J Clin Pharmacol. 2002 Sep;54(3):269-76. doi: 10.1046/j.1365-2125.2002.01638.x. PMID: 12236847; PMCID: PMC1874419.