MedKoo Cat#: 577535 | Name: Rizatriptan sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rizatriptan sulfate is a selective serotonin 5-HTID receptor agonist derived from tryptamine.

Chemical Structure

Rizatriptan sulfate
Rizatriptan sulfate
CAS#159776-67-7

Theoretical Analysis

MedKoo Cat#: 577535

Name: Rizatriptan sulfate

CAS#: 159776-67-7

Chemical Formula: C15H21N5O4S

Exact Mass: 367.1314

Molecular Weight: 367.42

Elemental Analysis: C, 49.03; H, 5.76; N, 19.06; O, 17.42; S, 8.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-A462; MK A462; MKA462; Rizatriptan sulfate
IUPAC/Chemical Name
1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, monosulfate
InChi Key
SMWLLNMVQNVPLD-UHFFFAOYSA-N
InChi Code
InChI=1S/2C15H19N5.H2O4S.H2O/c2*1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;1-5(2,3)4;/h2*3-4,7-8,10-11,17H,5-6,9H2,1-2H3;(H2,1,2,3,4);1H2
SMILES Code
O.CN(C)CCc1c[nH]c2ccc(Cn3cncn3)cc12.CN(C)CCc4c[nH]c5ccc(Cn6cncn6)cc45.OS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bhagawati ST, Chonkar AD, Dengale SJ, Reddy M S, Bhat K. Bioavailability enhancement of rizatriptan benzoate by oral disintegrating strip: In vitro and in vivo evaluation. Curr Drug Deliv. 2015 Aug 27. [Epub ahead of print] PubMed PMID: 26310617. 2: Yao G, Man Y, Luo X, Yu T, Ji L. Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine. Neural Regen Res. 2012 Jan 15;7(2):131-5. doi: 10.3969/j.issn.1673-5374.2012.02.009. PubMed PMID: 25767488; PubMed Central PMCID: PMC4354128. 3: Sundar BS, Suneetha A. Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets. Indian J Pharm Sci. 2010 Nov;72(6):798-801. doi: 10.4103/0250-474X.84601. PubMed PMID: 21969758; PubMed Central PMCID: PMC3178987. 4: Keny RV, Desouza C, Lourenco CF. Formulation and evaluation of rizatriptan benzoate mouth disintegrating tablets. Indian J Pharm Sci. 2010 Jan;72(1):79-85. doi: 10.4103/0250-474X.62253. PubMed PMID: 20582194; PubMed Central PMCID: PMC2883231.