MedKoo Cat#: 577528 | Name: MK-7128

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-7128 is a CB1 receptor inverse agonist.

Chemical Structure

MK-7128
MK-7128
CAS#937731-95-8

Theoretical Analysis

MedKoo Cat#: 577528

Name: MK-7128

CAS#: 937731-95-8

Chemical Formula: C29H25ClF2N4O2

Exact Mass: 534.1634

Molecular Weight: 534.99

Elemental Analysis: C, 65.11; H, 4.71; Cl, 6.63; F, 7.10; N, 10.47; O, 5.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-7128; MK 7128; MK7128
IUPAC/Chemical Name
3-((1S)-1-(1-((1S)-(4-Chlorophenyl)(3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl)methyl)azetidin-3-yl)-2-fluoro-2-methylpropyl)-5-fluorobenzonitrile
InChi Key
WFYMIOTUYKCVRZ-FTJBHMTQSA-N
InChi Code
InChI=1S/C29H25ClF2N4O2/c1-29(2,32)25(21-10-17(14-33)11-24(31)13-21)22-15-36(16-22)26(18-6-8-23(30)9-7-18)19-4-3-5-20(12-19)27-34-35-28(37)38-27/h3-13,22,25-26H,15-16H2,1-2H3,(H,35,37)/t25-,26+/m1/s1
SMILES Code
CC(C)(F)[C@@H](C1CN(C1)[C@@H](c2ccc(Cl)cc2)c3cccc(c3)C4=NNC(=O)O4)c5cc(F)cc(c5)C#N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Dillon GM, Lubbers LS, Ferguson MT, Lao JZ, Huang RR, Xiao JC, Fong TM, Hale JJ, Rupprecht K, Miao S, Rowe BA, Kornecook TJ, Dodart JC. MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice. Behav Pharmacol. 2011 Apr;22(2):91-100. doi: 10.1097/FBP.0b013e3283423d7e. PMID: 21301326.