NMS-P293, also known as NMS 03305293, is a PARP-1 selective inhibitor with no trapping activity and high CNS penetration, possesses potent in vivo efficacy and represents a novel therapeutic option for brain localized metastases and glioblastoma. NMS-P293 possesses favourable drug-like characteristics, which include high in vitro cross-species metabolic stability, lack of cytochrome interaction, and excellent pharmacokinetic profile, with low clearance and nearly complete oral bioavailability in both rodents and non rodents.
MedKoo Cat#: 207167
Name: NMS-P293
CAS#: 1606996-12-6
Chemical Formula:
Exact Mass: 0.0000
Molecular Weight: 0.00
Elemental Analysis:
The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
