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MedKoo Cat#: 577489 | Name: Soterenol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Soterenol hydrochloride is an adrenergic beta-2 agonist used as bronchodilator and has a number of gastrointestinal side effects.

Chemical Structure

Soterenol hydrochloride
Soterenol hydrochloride
CAS#14816-67-2

Theoretical Analysis

MedKoo Cat#: 577489

Name: Soterenol hydrochloride

CAS#: 14816-67-2

Chemical Formula: C12H21ClN2O4S

Exact Mass: 324.0911

Molecular Weight: 324.82

Elemental Analysis: C, 44.37; H, 6.52; Cl, 10.91; N, 8.62; O, 19.70; S, 9.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MJ 1992; MJ1992; MJ-1992; Soterenol hydrochloride; Soterenol HCl
IUPAC/Chemical Name
Methanesulfonamide, N-(2-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-, monohydrochloride
InChi Key
LTQWQTNRIBKUMN-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H20N2O4S.ClH/c1-8(2)13-7-12(16)9-4-5-11(15)10(6-9)14-19(3,17)18;/h4-6,8,12-16H,7H2,1-3H3;1H
SMILES Code
Cl.CC(C)NCC(O)c1ccc(O)c(NS(=O)(=O)C)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Borda E, del C Agostini M, Gimeno MF, Gimeno AL. Selective stimulation of PGE1-synthesis by soterenol in the isolated rat vas deferens is mediated by alpha adrenoreceptors. Prostaglandins Leukot Med. 1982 May;8(5):531-6. PubMed PMID: 6285389. 2: Kensler TT, Brooke D, Walker DM. Application of trihydroxyindole reaction to methanesulfonanilides: fluorometric analysis for soterenol and mesuprine. J Pharm Sci. 1976 May;65(5):763-4. PubMed PMID: 6778. 3: Kitagawa H, Yamauchi A, Shibata S. Potent alpha-adrenoceptor action of soterenol on vascular and other smooth muscle. Eur J Pharmacol. 1975 Aug;33(1):227-30. PubMed PMID: 240730. 4: Keh GS, Kearney PE, Raper C. Comparison of the beta-adrenoceptor effects of soterenol and its 3-hydroxy, 4-sulphonamido isomer (MJ6987-1) in isolated tissues from the guninea-pig. Clin Exp Pharmacol Physiol. 1979 Jul-Aug;6(4):409-13. PubMed PMID: 39696. 5: Malta E, Raper C. Influence of changes in amine substitution on the beta-adrenoceptor stimulant activity of soterenol and related compounds in the anaesthetized cat. Clin Exp Pharmacol Physiol. 1975 Jul-Aug;2(4):359-63. PubMed PMID: 238779. 6: Farmer JB, Levy GP, Marshall RJ. A comparison of the beta-adrenoceptor stimulant properties of salbutamol, orciprenaline and soterenol with those of isoprenaline. J Pharm Pharmacol. 1970 Dec;22(12):945-7. PubMed PMID: 4395522. 7: Dungan KW, Cho YW, Gomoll AW, Aviado DM, Lish PM. Pharmacologic potency and selectivity of a new bronchodilator agent: soterenol (MJ 1992). J Pharmacol Exp Ther. 1968 Dec;164(2):290-301. PubMed PMID: 5699090. 8: Buckner CK, Saini RK. On the use of functional antagonism to estimate dissociation constants for beta adrenergic receptor agonists in isolated guinea-pig trachea. J Pharmacol Exp Ther. 1975 Sep;194(3):565-74. PubMed PMID: 240019. 9: Farmer JB, Levy GP. Comparative beta-adrenoceptive stimulant properties of salbutamol (AH 3365), orciprenaline and soterenol (MJ 1992). Br J Pharmacol. 1969 Feb;35(2):P358-9. PubMed PMID: 5774057; PubMed Central PMCID: PMC1703250. 10: Farmer JB, Kennedy I, Levy GP, Marshall RJ. A comparison of the beta-adrenoreceptor stimulant properties of isoprenaline, with those of orciprenaline, salbutamol, soterenol and trimetoquinol on isolated atria and trachea of the guinea pig. J Pharm Pharmacol. 1970 Jan;22(1):61-3. PubMed PMID: 4391750. 11: Buckner CK, Abel P. Studies on the effects of enantiomers of soterenol, trimetoquinol and salbutamol on beta adrenergic receptors of isolated guinea-pig atria and trachea. J Pharmacol Exp Ther. 1974 Jun;189(3):616-25. PubMed PMID: 4152313. 12: Aiggilo DA, Brown JH, Murray HL. Hyperglycemic and hyperlactic acidemic effects of soterenol (MJ 1992). Proc Soc Exp Biol Med. 1969 Nov;132(2):679-82. PubMed PMID: 5355125. 13: Marmo E. [Effects of terbutalin on the cardiovascular system and tracheo-bronchial, gastrointestinal, splenic and differential musculature. Experimental comparative research with isoprenaline, metaproterenol, soterenol, salbutamol, chlorprenaline, isoxysuprin and quinterenol]. Farmaco Prat. 1971 Aug;26(8):426-97. Italian. PubMed PMID: 4398396. 14: Spadari RC, de Moraes S. Subsensitivity to beta-adrenoceptor agonists in pacemakers isolated from senescent rats. Gen Pharmacol. 1991;22(5):917-21. PubMed PMID: 1684771. 15: Buckner CK, Torphy T, Costa DJ. Studies on beta-adrenoceptors mediating changes in mechanical events and adenosine 3',5'-monophosphate levels. Rat atria. Eur J Pharmacol. 1978 Feb 1;47(3):259-71. PubMed PMID: 24540. 16: Busch L, Sterin-Borda L, Borda E. Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Arch Oral Biol. 2008 Jun;53(6):509-16. doi: 10.1016/j.archoralbio.2007.12.010. Epub 2008 Feb 13. PubMed PMID: 18275933. 17: Malta E, Raper C. Soterenol and related compounds: molecular modifications and changes in selectivity, affinity and efficacy at beta-adrenoreceptors in guinea-pig atria and trachea. Clin Exp Pharmacol Physiol. 1977 Jul-Aug;4(4):425-9. PubMed PMID: 20258. 18: Zwadyk P Jr, Harrison EF. Comparison of the protective properties of soterenol and isoproterenol against endotoxin lethality. Proc Soc Exp Biol Med. 1970 Jan;133(1):66-8. PubMed PMID: 4904565. 19: Cohen BM. Preliminary titration of the airway effects of a new bronchodilator aerosol (soterenol, MJ 1992) in humans with obstructive ventilatory disorders. Curr Ther Res Clin Exp. 1969 Dec;11(12):713-26. PubMed PMID: 4984035. 20: Cho YW, Aviado DM, Lish PM. Efficacy of a new bronchodilator, soterenol, on experimental locked-lung syndrome in dogs. J Allergy. 1968 Jul;42(1):36-48. PubMed PMID: 5243797.