CNY-07 | CAS#unknown | Nec-1s analogue

MedKoo Cat#: 465617 | Name: CNY-07

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CNY-07 is an analogue of Nec-1s, a RIPK1/necroptosis inhibitor. [18F]CNY-07 is a fluorine-18 (F-18)-labeled analogue of Nec-1s. It can be used as a brain penetrating and specific RIPK1 PET imaging probe.

Chemical Structure

CNY-07

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465617

Name: CNY-07

CAS#: unknown

Chemical Formula: C13H12FN3O2

Exact Mass: 261.0914

Molecular Weight: 261.26

Elemental Analysis: C, 59.77; H, 4.63; F, 7.27; N, 16.08; O, 12.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CNY-07; CNY07; CNY 07;

IUPAC/Chemical Name

5-((7-fluoro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione

InChi Key

CLKODKITOFTOSQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H12FN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)

SMILES Code

FC1=CC=CC2=C1NC=C2CC3NC(N(C)C3=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 261.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lan Y, Bai P, Liu Y, Afshar S, Striar R, Rattray AK, Meyer TN, Langan AG, Posner AM, Shen S, Tanzi RE, Zhang C, Wang C. Visualization of Receptor- Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography. J Med Chem. 2021 Oct 15. doi: 10.1021/acs.jmedchem.1c01477. Epub ahead of print. PMID: 34652135.