PROTAC(H-PGDS)-7 is a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase. PROTAC(H-PGDS)-7 (6), which showed potent and selective degradation activity (DC50 = 17.3 pM) and potent suppression of prostaglandin D2 production in KU812 cells. Additionally, in a Duchenne muscular dystrophy model using mdx mice with cardiac hypertrophy, PROTAC(H-PGDS)-7 showed better inhibition of inflammatory cytokines than a potent H-PGDS inhibitor TFC-007.
MedKoo Cat#: 465616
Name: PROTAC(H-PGDS)-7
CAS#: unknown
Chemical Formula: C40H38N8O7
Exact Mass: 742.2863
Molecular Weight: 742.79
Elemental Analysis: C, 64.68; H, 5.16; N, 15.09; O, 15.08
The following data is based on the product molecular weight 742.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
