Desmethyl-ER176 | CAS#1373887-55-8

MedKoo Cat#: 556032 | Name: Desmethyl-ER176

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desmethyl-ER176 is a precursor for synthesis of PET tracer [11C]ER176. [11C]ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein, a biomarker for neuroinflammation. 11C-ER176 sas Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.

Chemical Structure

Desmethyl-ER176

CAS#1373887-55-8

Theoretical Analysis

MedKoo Cat#: 556032

Name: Desmethyl-ER176

CAS#: 1373887-55-8

Chemical Formula: C19H18ClN3O

Exact Mass: 339.1138

Molecular Weight: 339.82

Elemental Analysis: C, 67.16; H, 5.34; Cl, 10.43; N, 12.37; O, 4.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Desmethyl-ER176; Desmethyl-ER-176; Desmethyl-ER 176;

IUPAC/Chemical Name

4-(2-Chlorophenyl)-N-[(1R)-1-methylpropyl]-2-quinazolinecarboxamide

InChi Key

TZELXYVPZOAABL-GFCCVEGCSA-N

InChi Code

InChI=1S/C19H18ClN3O/c1-3-12(2)21-19(24)18-22-16-11-7-5-9-14(16)17(23-18)13-8-4-6-10-15(13)20/h4-12H,3H2,1-2H3,(H,21,24)/t12-/m1/s1

SMILES Code

O=C(C1=NC(C2=CC=CC=C2Cl)=C3C=CC=CC3=N1)N[C@H](C)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 339.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mixdorf JC, Murali D, Xin Y, DiFilippo AH, Aluicio-Sarduy E, Barnhart TE, Engle JW, Ellison PA, Christian BT. Alternative strategies for the synthesis of [11C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954. doi: 10.1016/j.apradiso.2021.109954. Epub ahead of print. PMID: 34607293. 2: Hong J, Telu S, Zhang Y, Miller WH, Shetty HU, Morse CL, Pike VW. Translation of 11C-labeled tracer synthesis to a CGMP environment as exemplified by [11C]ER176 for PET imaging of human TSPO. Nat Protoc. 2021 Sep;16(9):4419-4445. doi: 10.1038/s41596-021-00584-4. Epub 2021 Aug 6. PMID: 34363068. 3: Rocha NP, Charron O, Latham LB, Colpo GD, Zanotti-Fregonara P, Yu M, Freeman L, Furr Stimming E, Teixeira AL. Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology. Neurol Neuroimmunol Neuroinflamm. 2021 Apr 1;8(3):e984. doi: 10.1212/NXI.0000000000000984. PMID: 33795375; PMCID: PMC8017723. 4: Veronese M, Tuosto M, Marques TR, Howes O, Pascual B, Yu M, Masdeu JC, Turkheimer F, Bertoldo A, Zanotti-Fregonara P. Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function. Mol Imaging Biol. 2021 Aug;23(4):560-571. doi: 10.1007/s11307-020-01575-9. Epub 2021 Jan 21. PMID: 33475944; PMCID: PMC8277653. 5: Zanotti-Fregonara P, Pascual B, Veronese M, Yu M, Beers D, Appel SH, Masdeu JC. Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain. Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1822-1829. doi: 10.1007/s00259-019-04349-w. Epub 2019 May 31. PMID: 31152207. 6: Fujita M, Kobayashi M, Ikawa M, Gunn RN, Rabiner EA, Owen DR, Zoghbi SS, Haskali MB, Telu S, Pike VW, Innis RB. Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7(1):84. doi: 10.1186/s13550-017-0334-8. PMID: 29038960; PMCID: PMC5643834. 7: Ikawa M, Lohith TG, Shrestha S, Telu S, Zoghbi SS, Castellano S, Taliani S, Da Settimo F, Fujita M, Pike VW, Innis RB; Biomarkers Consortium Radioligand Project Team. 11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain. J Nucl Med. 2017 Feb;58(2):320-325. doi: 10.2967/jnumed.116.178996. Epub 2016 Nov 17. PMID: 27856631; PMCID: PMC5288742.

View History

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