K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.
MedKoo Cat#: 465600
Name: K34c
CAS#: 939769-93-4
Chemical Formula: C26H29N3O4
Exact Mass: 447.2158
Molecular Weight: 447.54
Elemental Analysis: C, 69.78; H, 6.53; N, 9.39; O, 14.30
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.8 | 100.00 | |
| Ethanol | 44.8 | 100.00 |
The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
