MedKoo Cat#: 471060 | Name: HPK1-IN-7
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HPK1-IN-7 is a potent, orally active HPK1 inhibitor. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

Chemical Structure

HPK1-IN-7
HPK1-IN-7
CAS#2320462-65-3

Theoretical Analysis

MedKoo Cat#: 471060

Name: HPK1-IN-7

CAS#: 2320462-65-3

Chemical Formula: C24H22N6O4

Exact Mass: 458.1703

Molecular Weight: 458.48

Elemental Analysis: C, 62.87; H, 4.84; N, 18.33; O, 13.96

Price and Availability

Size Price Availability Quantity
25mg USD 850.00 2 Weeks
50mg USD 1,450.00 2 Weeks
100mg USD 2,450.00 2 Weeks
200mg USD 3,950.00 2 Weeks
500mg USD 4,950.00 2 Weeks
1g USD 6,950.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
HPK1-IN-7 ; HPK1-IN 7, HPK1-IN7
IUPAC/Chemical Name
(S)-5-((4-((2-hydroxy-1-phenylethyl)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one
InChi Key
RVSSNRBUPQUIEG-LJQANCHMSA-N
InChi Code
InChI=1S/C24H22N6O4/c1-24(2)18-10-15(8-9-16(18)22(32)34-24)27-23-25-11-17(21-30-26-13-33-21)20(29-23)28-19(12-31)14-6-4-3-5-7-14/h3-11,13,19,31H,12H2,1-2H3,(H2,25,27,28,29)/t19-/m1/s1
SMILES Code
OC[C@@H](NC1=NC(NC2=CC(C3(C)C)=C(C(O3)=O)C=C2)=NC=C1C4=NN=CO4)C5=CC=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 458.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Degnan AP, et al. Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. ACS Med Chem Lett. 2021;12(3):443-450.