Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor (EC50 = 1−15 nM). Ac32Az19 remarkably exhibits a 100% 5D3 shift, indicating that it can bind and cause a conformational change of BCRP. Moreover, it significantly reduces the abundance of functional BCRP dimers/oligomers by half to retain more mitoxantrone in the BCRP-overexpressing cell line and that may account for its inhibitory activity.
MedKoo Cat#: 465587
Name: Ac32Az19
CAS#: unknown
Chemical Formula: C37H33N3O6
Exact Mass: 615.2369
Molecular Weight: 615.69
Elemental Analysis: C, 72.18; H, 5.40; N, 6.83; O, 15.59
The following data is based on the product molecular weight 615.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
