AS-0141 | CAS1402057-88-8 | CDC7 Kinase Inhibitor

MedKoo Cat#: 465584 | Name: AS-0141 was removed

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS-0141 was removed for commercial reason.

Chemical Structure

AS-0141 was removed

CAS#1402057-88-8

Theoretical Analysis

MedKoo Cat#: 465584

Name: AS-0141 was removed

CAS#: 1402057-88-8

Chemical Formula: C21H22F3N5O4

Exact Mass: 465.1624

Molecular Weight: 465.43

Elemental Analysis: C, 54.19; H, 4.76; F, 12.25; N, 15.05; O, 13.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AS-0141; AS0141; AS 0141; Monzosertib;

IUPAC/Chemical Name

ethyl (E)-5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methylene)-4-oxo-2-((4-(2,2,2-trifluoroethyl)piperazin-1-yl)amino)-4,5-dihydrofuran-3-carboxylate

InChi Key

DNTVXDZWVOVLOD-XNTDXEJSSA-N

InChi Code

InChI=1S/C21H22F3N5O4/c1-2-32-20(31)16-17(30)15(10-13-11-26-18-14(13)4-3-5-25-18)33-19(16)27-29-8-6-28(7-9-29)12-21(22,23)24/h3-5,10-11,27H,2,6-9,12H2,1H3,(H,25,26)/b15-10+

SMILES Code

FC(F)(F)CN1CCN(NC(O/C2=C/C3=CNC4=NC=CC=C43)=C(C(OCC)=O)C2=O)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 465.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Irie T, Asami T, Sawa A, Uno Y, Taniyama C, Funakoshi Y, Masai H, Sawa M. Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers. J Med Chem. 2021 Oct 5. doi: 10.1021/acs.jmedchem.1c01319. Epub ahead of print. PMID: 34607435.