JNJ-67569762 | CAS#2380313-26-6 | BACE1 inhibitor

MedKoo Cat#: 465568 | Name: JNJ-67569762

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-67569762 is a potent and selective BACE1 inhibitor. JNJ-67569762 gave robust dose-dependent BACE1-mediated amyloid β lowering without showing BACE2-dependent hair depigmentation in preclinical models.

Chemical Structure

JNJ-67569762

CAS#2380313-26-6

Theoretical Analysis

MedKoo Cat#: 465568

Name: JNJ-67569762

CAS#: 2380313-26-6

Chemical Formula: C22H22F4N4O5S

Exact Mass: 530.1247

Molecular Weight: 530.49

Elemental Analysis: C, 49.81; H, 4.18; F, 14.33; N, 10.56; O, 15.08; S, 6.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JNJ-67569762; JNJ67569762; JNJ 67569762;

IUPAC/Chemical Name

N-(3-((2S,5R)-6-amino-5-(ethylsulfonyl)-2-(fluoromethyl)-5-methyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide

InChi Key

NDIQAOIHFVWZJQ-NHCUHLMSSA-N

InChi Code

InChI=1S/C22H22F4N4O5S/c1-3-36(32,33)20(2)6-7-21(11-23,30-19(20)27)13-8-12(4-5-14(13)24)29-18(31)15-9-16-17(10-28-15)35-22(25,26)34-16/h4-5,8-10H,3,6-7,11H2,1-2H3,(H2,27,30)(H,29,31)/t20-,21-/m1/s1

SMILES Code

FC(O1)(F)OC2=C1C=C(C(NC3=CC=C(F)C([C@]4(CF)CC[C@](S(=O)(CC)=O)(C)C(N)=N4)=C3)=O)N=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 530.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rombouts FJR, Kusakabe KI, Alexander R, Austin N, Borghys H, De Cleyn M, Dhuyvetter D, Gijsen HJM, Hrupka B, Jacobs T, Jerhaoui S, Lammens L, Leclercq L, Tsubone K, Ueno T, Morimoto K, Einaru S, Sumiyoshi H, Van den Bergh A, Vos A, Surkyn M, Teisman A, Moechars D. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Sep 23. doi: 10.1021/acs.jmedchem.1c00935. Epub ahead of print. PMID: 34553934.