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MedKoo Cat#: 577458 | Name: MI-219 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MI-219 hydrochloride is a biochemical that targets the E3 enzyme and may be useful in preclinical cancer treatment.

Chemical Structure

MI-219 hydrochloride
MI-219 hydrochloride
CAS#1201143-87-4

Theoretical Analysis

MedKoo Cat#: 577458

Name: MI-219 hydrochloride

CAS#: 1201143-87-4

Chemical Formula: C27H33Cl3FN3O4

Exact Mass: 587.1521

Molecular Weight: 588.93

Elemental Analysis: C, 55.07; H, 5.65; Cl, 18.06; F, 3.23; N, 7.14; O, 10.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
MI 219; MI219; MI-219; MI-219 hydrochloride; MI-219 HCl
IUPAC/Chemical Name
Spiro(3H-indole-3,3'-pyrrolidine)-5'-carboxamide, 6-chloro-4'-(3-chlorophenyl)-N-((3S)-3,4-dihydroxybutyl)-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxo-, hydrochloride (1:1), (2'R,3S,4'R,5'R)
InChi Key
FCPJMURCXCSVLM-KVUUDYJHSA-N
InChi Code
1S/C27H32Cl2FN3O4.ClH/c1-26(2,3)12-21-27(17-10-19(30)18(29)11-20(17)32-25(27)37)22(14-5-4-6-15(28)9-14)23(33-21)24(36)31-8-7-16(35)13-34;/h4-6,9-11,16,21-23,33-35H,7-8,12-13H2,1-3H3,(H,31,36)(H,32,37);1H/t16-,21+,22-,23+,27-;/m0./s1
SMILES Code
Cl.CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]13C(=O)Nc4cc(Cl)c(F)cc34)C(=O)NCC[C@H](O)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 588.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Deng L, Meng T, Chen L, Wei W, Wang P. The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduct Target Ther. 2020 Feb 29;5(1):11. doi: 10.1038/s41392-020-0107-0. PMID: 32296023; PMCID: PMC7048745. 2. Zheng M, Yang J, Xu X, Sebolt JT, Wang S, Sun Y. Efficacy of MDM2 inhibitor MI-219 against lung cancer cells alone or in combination with MDM2 knockdown, a XIAP inhibitor or etoposide. Anticancer Res. 2010 Sep;30(9):3321-31. PMID: 20944104.