JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.
MedKoo Cat#: 465566
Name: JW 480
CAS#: 1354359-53-7
Chemical Formula: C22H23NO2
Exact Mass: 333.1729
Molecular Weight: 333.43
Elemental Analysis: C, 79.25; H, 6.95; N, 4.20; O, 9.60
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.3 | 100.00 | |
| Ethanol | 33.3 | 100.00 |
The following data is based on the product molecular weight 333.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
