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MedKoo Cat#: 577446 | Name: Endralazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Endralazine is a peripheral vasodilator with antihypertensive activity.

Chemical Structure

Endralazine
Endralazine
CAS#39715-02-1

Theoretical Analysis

MedKoo Cat#: 577446

Name: Endralazine

CAS#: 39715-02-1

Chemical Formula: C14H15N5O

Exact Mass: 269.1277

Molecular Weight: 269.31

Elemental Analysis: C, 62.44; H, 5.61; N, 26.01; O, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BQ 22-708; BQ22-708; BQ-22-708; Endralazine
IUPAC/Chemical Name
Pyrido(4,3-c)pyridazin-3(2H)-one, 6-benzoyl-5,6,7,8-tetrahydro-, 3-hydrazone
InChi Key
ALAXZYHFVBSJKZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15N5O/c15-16-13-8-11-9-19(7-6-12(11)17-18-13)14(20)10-4-2-1-3-5-10/h1-5,8H,6-7,9,15H2,(H,16,18)
SMILES Code
NNc1cc2CN(CCc2nn1)C(=O)c3ccccc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 269.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Chazan BI, Duff DA, McCallum A, Whaley K. Comparative study of endralazine and hydralazine for the treatment of hypertension uncontrolled by a beta-blocker and diuretic. Curr Med Res Opin. 1986;10(3):150-8. doi: 10.1185/03007998609110434. PMID: 2873966. 2. Bogers WA, Meems L. Endralazine, a new peripheral vasodilator. Evaluation of safety and efficacy over a 3 year period. Eur J Clin Pharmacol. 1983;24(3):301-5. doi: 10.1007/BF00610045. PMID: 6861845. 3. Higgs ER, Harrison PR, Banks RA, Kingswood JC, Mackenzie JC. Endralazine in patients with severe hypertension and renal insufficiency. Postgrad Med J. 1982 Dec;58(686):767-70. doi: 10.1136/pgmj.58.686.767. PMID: 6984902; PMCID: PMC2426600.