Neostigmine hydroxide | CAS# 588-17-0 | Biochemical

MedKoo Cat#: 577432 | Name: Neostigmine hydroxide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neostigmine hydroxide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Chemical Structure

Neostigmine hydroxide

CAS#588-17-0

Theoretical Analysis

MedKoo Cat#: 577432

Name: Neostigmine hydroxide

CAS#: 588-17-0

Chemical Formula: C12H20N2O3

Exact Mass: 240.1474

Molecular Weight: 240.30

Elemental Analysis: C, 59.98; H, 8.39; N, 11.66; O, 19.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Neostigmine hydroxide

IUPAC/Chemical Name

Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-, hydroxide (1:1)

InChi Key

GTPJMRHVDZUPND-UHFFFAOYSA-M

InChi Code

InChI=1S/C12H19N2O2.H2O/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H2/q+1;/p-1

SMILES Code

[OH-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 240.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Yang L, Yang D, Li Q, Zuo Y, Lu D. Neostigmine for reversal of neuromuscular block in paediatric patients. Cochrane Database Syst Rev. 2014 May 5;(5):CD010110. doi: 10.1002/14651858.CD010110.pub2. PMID: 24793636.