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MedKoo Cat#: 415007 | Name: Pirogliride tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pirogliride tartrate is an Antidiabetic

Chemical Structure

Pirogliride tartrate
Pirogliride tartrate
CAS#62625-19-8 (tartrate)

Theoretical Analysis

MedKoo Cat#: 415007

Name: Pirogliride tartrate

CAS#: 62625-19-8 (tartrate)

Chemical Formula: C20H28N4O6

Exact Mass:

Molecular Weight: 420.47

Elemental Analysis: C, 57.13; H, 6.71; N, 13.33; O, 22.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
62625-18-7 (free base); 62625-19-8 (tartrate)
Synonym
Pirogliride tartrate; NSC 352123; NSC352123; NSC-352123; McN3495; McN 3495; McN-3495
IUPAC/Chemical Name
1-Pyrrolidinecarboximidamide, N-(1-methyl-2-pyrrolidinylidene)-N'-phenyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1)
InChi Key
POCOFJTXQYWTDN-MHKMFBJXSA-N
InChi Code
InChI=1S/C16H22N4.C4H6O6/c1-19-11-7-10-15(19)18-16(20-12-5-6-13-20)17-14-8-3-2-4-9-14;5-1(3(7)8)2(6)4(9)10/h2-4,8-9H,5-7,10-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/b17-16-,18-15+;/t;1-,2-/m.1/s1
SMILES Code
CN1/C(CCC1)=N/C(N2CCCC2)=N/C3=CC=CC=C3.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zawalich WS, Weill VA, Matschinsky FM. Pirogliride: an oral hypoglycemic drug which accelerates glucose usage and insulin secretion by islets of Langerhans. Diabetes. 1980 May;29(5):410-2. doi: 10.2337/diab.29.5.410. PMID: 6991332. 2: Wu WN. Metabolic fate of the hypoglycemic agent pirogliride in laboratory animals and humans. J Pharm Biomed Anal. 1998 Aug;17(4-5):689-97. doi: 10.1016/s0731-7085(97)00252-5. PMID: 9682152. 3: Tutwiler GF. Effect of the oral hypoglycemic agent, pirogliride, on lipolysis. Biochem Med. 1979 Oct;22(2):204-13. doi: 10.1016/0006-2944(79)90007-3. PMID: 518576. 4: Tutwiler GF, Fawthrop H. Effect of the oral hypoglycemic agent pirogliride (McN-3495) on glycogen levels of normal and diabetic rats. Biochem Int. 1983 Jul;7(1):55-62. PMID: 6383388. 5: Tutwiler GF, Brentzel HJ. Effect of the oral hypoglycemic agent, pirogliride, on gluconeogenesis. Biochem Pharmacol. 1980 May 15;29(10):1421-7. doi: 10.1016/0006-2952(80)90438-4. PMID: 7396976. 6: Tutwiler GJ, Fawthrop HC, Krill RT, Pek S. Effect of the oral hypoglycemic agent pirogliride tartrate on insulin and glucagon secretion in vivo and in vitro. Adv Exp Med Biol. 1979;119:435-41. doi: 10.1007/978-1-4615-9110-8_63. PMID: 386729. 7: Salhanick AI, Leighty SJ, Amatruda JM. Postreceptor regulation of insulin action in primary cultures of rat hepatocytes by oral hypoglycemic agents: effects of linogliride and chlorpropamide. Horm Metab Res. 1989 Nov;21(11):596-601. doi: 10.1055/s-2007-1009297. PMID: 2687145. 8: Johnson DG, Bressler R. New pharmacologic approaches to the treatment of diabetes. Spec Top Endocrinol Metab. 1984;6:163-92. PMID: 6151747. 9: Doi K. [New oral antidiabetic agents]. Nihon Rinsho. 1990 Dec;48 Suppl:962-73. Japanese. PMID: 2128351.