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MedKoo Cat#: 415005 | Name: Piroctone Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piroctone Free Base is an Antiseborrheic

Chemical Structure

Piroctone Free Base
Piroctone Free Base
CAS#50650-76-5 (free base)

Theoretical Analysis

MedKoo Cat#: 415005

Name: Piroctone Free Base

CAS#: 50650-76-5 (free base)

Chemical Formula: C14H23NO2

Exact Mass: 237.1729

Molecular Weight: 237.34

Elemental Analysis: C, 70.85; H, 9.77; N, 5.90; O, 13.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
50650-76-5 (free base); 68890-66-4 (olamine)
Synonym
Piroctone Free Base; Piroctona; Piroctonum
IUPAC/Chemical Name
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-
InChi Key
OIQJEQLSYJSNDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H23NO2/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5/h6,8,11,17H,7,9H2,1-5H3
SMILES Code
O=C1C=C(C)C=C(CC(C)CC(C)(C)C)N1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Piquero-Casals J, Hexsel D, Mir-Bonafé JF, Rozas-Muñoz E. Topical Non- Pharmacological Treatment for Facial Seborrheic Dermatitis. Dermatol Ther (Heidelb). 2019 Sep;9(3):469-477. doi: 10.1007/s13555-019-00319-0. Epub 2019 Aug 8. PMID: 31396944; PMCID: PMC6704200. 2: do Couto FM, do Nascimento SC, Júnior SF, da Silva VK, Leal AF, Neves RP. Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis. Springerplus. 2016 Apr 16;5:468. doi: 10.1186/s40064-016-2130-8. PMID: 27119072; PMCID: PMC4833761. 3: Piquero-Casals J, La Rotta-Higuera E, Francisco Mir-Bonafé J, Rozas-Muñoz E, Granger C. Non-Steroidal Topical Therapy for Facial Seborrheic Dermatitis. J Drugs Dermatol. 2020 Jun 1;19(6):658-660. doi: 10.36849/JDD.2020.10.36849/JDD.2020.5121. PMID: 32574015. 4: Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt- Wolf IG. Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. In Vivo. 2011 Jan-Feb;25(1):99-103. PMID: 21282741. 5: Schmidt-Rose T, Braren S, Fölster H, Hillemann T, Oltrogge B, Philipp P, Weets G, Fey S. Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. Int J Cosmet Sci. 2011 Jun;33(3):276-82. doi: 10.1111/j.1468-2494.2010.00623.x. Epub 2011 Jan 27. PMID: 21272039. 6: Puviani M, Campione E, Offidani AM, De Grandi R, Bianchi L, Bobyr I, Giannoni M, Campanati A, Bottagisio M, Bidossi A, De Vecchi E, Eisendle K, Milani M. Effects of a cream containing 5% hyaluronic acid mixed with a bacterial-wall- derived glycoprotein, glycyrretinic acid, piroctone olamine and climbazole on signs, symptoms and skin bacterial microbiota in subjects with seborrheic dermatitis of the face. Clin Cosmet Investig Dermatol. 2019 May 2;12:285-293. doi: 10.2147/CCID.S205904. PMID: 31190937; PMCID: PMC6525831. 7: Albalawi AE, Khalaf AK, Alyousif MS, Alanazi AD, Baharvand P, Shakibaie M, Mahmoudvand H. Fe3O4@piroctone olamine magnetic nanoparticles: Synthesize and therapeutic potential in cutaneous leishmaniasis. Biomed Pharmacother. 2021 Jul;139:111566. doi: 10.1016/j.biopha.2021.111566. Epub 2021 Apr 8. PMID: 33839494. 8: Allgood GS, Miller JM, Schardein JL. The effect of piroctone olamine on reproduction of male and female rats. Fundam Appl Toxicol. 1991 Jan;16(1):31-40. doi: 10.1016/0272-0590(91)90132-n. PMID: 2019350. 9: Youn HJ, Kim SY, Park M, Jung WH, Lee YW, Choe YB, Ahn KJ. Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. Ann Dermatol. 2016 Dec;28(6):733-739. doi: 10.5021/ad.2016.28.6.733. Epub 2016 Nov 23. PMID: 27904273; PMCID: PMC5125955. 10: Sigle HC, Schäfer-Korting M, Korting HC, Hube B, Niewerth M. In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses. 2006 May;49(3):159-68. doi: 10.1111/j.1439-0507.2006.01228.x. PMID: 16681805.