Synonym
Minoxidil sulfate ester
IUPAC/Chemical Name
2-Pyrimidinamine, 1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-
InChi Key
KVOZMWUBYWDGEX-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
SMILES Code
NC1=NC(=CC(=N)N1OS(=O)(=O)O)N2CCCCC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
289.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gupta AK, Charrette A. Topical Minoxidil: Systematic Review and Meta-Analysis of Its Efficacy in Androgenetic Alopecia. Skinmed. 2015 May-Jun;13(3):185-9. Review. PubMed PMID: 26380504.
2: Gupta AK, Foley KA. 5% Minoxidil: treatment for female pattern hair loss. Skin Therapy Lett. 2014 Nov-Dec;19(6):5-7. Review. PubMed PMID: 25807073.
3: Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012 May;6(2):130-6. Review. PubMed PMID: 22409453.
4: Messenger AG, Rundegren J. Minoxidil: mechanisms of action on hair growth. Br J Dermatol. 2004 Feb;150(2):186-94. Review. PubMed PMID: 14996087.
5: Avram MR, Cole JP, Gandelman M, Haber R, Knudsen R, Leavitt MT, Leonard RT Jr, Puig CJ, Rose PT, Vogel JE, Ziering CL; Roundtable Consensus Meeting of The 9th Annual Meeting of The International Society of Hair Restoration Surgery. The potential role of minoxidil in the hair transplantation setting. Dermatol Surg. 2002 Oct;28(10):894-900; discussion 900. Review. PubMed PMID: 12410672.
6: Otomo S. [Hair growth effect of minoxidil]. Nihon Yakurigaku Zasshi. 2002 Mar;119(3):167-74. Review. Japanese. PubMed PMID: 11915519.
7: Sica DA, Gehr TW. Direct vasodilators and their role in hypertension management: minoxidil. J Clin Hypertens (Greenwich). 2001 Mar-Apr;3(2):110-4. Review. PubMed PMID: 11416693.
8: Dooley TP. Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin. Exp Dermatol. 1999 Aug;8(4):328-9. Review. PubMed PMID: 10439254.
9: Anderson RJ, Kudlacek PE, Clemens DL. Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact. 1998 Feb 20;109(1-3):53-67. Review. PubMed PMID: 9566733.
10: Wong WM, Seifert L. Minoxidil use in female alopecia. Ann Pharmacother. 1994 Jul-Aug;28(7-8):890-1. Review. PubMed PMID: 7949511.
11: Hong D, Hart LL. Topical minoxidil for hair loss in women. DICP. 1990 Nov;24(11):1062-3. Review. PubMed PMID: 2275230.
12: Colamarino R, Dubost JJ, Brun P, Flori B, Tournilhac M, Eschalier A, Sauvezie B. [Polymyalgia induced by topical minoxidil]. Ann Med Interne (Paris). 1990;141(5):425-8. Review. French. PubMed PMID: 2256586.
13: Brigham PA, Cappas A, Uno H. The stumptailed macaque as a model for androgenetic alopecia: effects of topical minoxidil analyzed by use of the folliculogram. Clin Dermatol. 1988 Oct-Dec;6(4):177-87. Review. PubMed PMID: 3063370.
14: Zins GR. The history of the development of minoxidil. Clin Dermatol. 1988 Oct-Dec;6(4):132-47. Review. PubMed PMID: 3063368.
15: Fiedler-Weiss VC. Minoxidil. Dermatol Clin. 1987 Jul;5(3):627-35. Review. PubMed PMID: 3301118.
16: Kvedar JC, Baden HP. Topical minoxidil in the treatment of male pattern alopecia. Pharmacotherapy. 1987;7(6):191-7. Review. PubMed PMID: 3328164.
17: Pinnell SR, Murad S. Effects of minoxidil on cultured human skin fibroblasts. Dermatologica. 1987;175 Suppl 2:12-8. Review. PubMed PMID: 2826267.
18: Hall D. [Minoxidil--profile of a new hypertensive agent]. MMW Munch Med Wochenschr. 1983 Nov 11;125(45):1033-6. Review. German. PubMed PMID: 6417524.
19: Linas SL, Nies AS. Minoxidil. Ann Intern Med. 1981 Jan;94(1):61-5. Review. PubMed PMID: 6108737.
20: Miller DD, Love DW. Evaluation of minoxidil. Am J Hosp Pharm. 1980 Jun;37(6):808-14. Review. PubMed PMID: 6994495.