MedKoo Cat#: 556028 | Name: AFN39186
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AFN39186, also known as RAD51-IN-1, is a derivative of B02 and a potent inhibitor of RAD51. AFN39186 was first reported in Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100.. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

AFN39186
AFN39186
CAS#2101739-18-6

Theoretical Analysis

MedKoo Cat#: 556028

Name: AFN39186

CAS#: 2101739-18-6

Chemical Formula: C22H16ClN3O

Exact Mass: 373.0982

Molecular Weight: 373.84

Elemental Analysis: C, 70.68; H, 4.31; Cl, 9.48; N, 11.24; O, 4.28

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 4,650.00 2 Weeks
2g USD 6,850.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
RAD51-IN-1; AFN39186; AFN-39186; AFN 39186; RAD51 Inhibitor 17
IUPAC/Chemical Name
(E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
InChi Key
AQNDWTVLZSMOQU-FMIVXFBMSA-N
InChi Code
InChI=1S/C22H16ClN3O/c23-18-10-7-17(8-11-18)15-26-21(12-9-16-4-3-13-24-14-16)25-20-6-2-1-5-19(20)22(26)27/h1-14H,15H2/b12-9+
SMILES Code
O=C1N(CC2=CC=C(Cl)C=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 373.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ward A, Dong L, Harris JM, Khanna KK, Al-Ejeh F, Fairlie DP, Wiegmans AP, Liu L. Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100. doi: 10.1016/j.bmcl.2017.05.039. Epub 2017 May 15. PMID: 28545975.