Related CAS #
60197-32-2 (HCl); 54341-02-5 (free base)
Synonym
Piflutixol Free Base; Piflutixolum
IUPAC/Chemical Name
1-(3-(6-Fluoro-2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-4-piperidineethanol
InChi Key
CCUOZZURYIZOKX-UYKKPYKBSA-N
InChi Code
InChI=1S/C24H25F4NOS/c25-18-4-5-20-19(2-1-10-29-11-7-16(8-12-29)9-13-30)21-14-17(24(26,27)28)3-6-22(21)31-23(20)15-18/h2-6,14-16,30H,1,7-13H2/b19-2-
SMILES Code
OCCC1CCN(CC/C=C2C3=C(SC4=C\2C=CC(F)=C4)C=CC(C(F)(F)F)=C3)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
451.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fleminger S. The relationship between the occupation of the D-1 dopamine receptor by [3H]piflutixol and the activity of dopamine-sensitive adenylate cyclase in rat striatal membranes. Biochem Pharmacol. 1991 Jul 5;42(2):229-37. doi: 10.1016/0006-2952(91)90708-d. PMID: 1650205.
2: Nielsen IM, Boeck V, Christensen AV, Danneskiold-Samsoe P, Hyttel J, Langeland J, Pedersen V, Svendsen O. The pharmacology of a new potent, long acting neuroleptic, piflutixol. Acta Pharmacol Toxicol (Copenh). 1977 Oct;41(4):369-83. doi: 10.1111/j.1600-0773.1977.tb02675.x. PMID: 579063.
3: Hyttel J. Similarities between the binding of 3H-piflutixol and 3H-flupentixol to rat striatal dopamine receptors in vitro. Life Sci. 1981 Feb 2;28(5):563-9. doi: 10.1016/0024-3205(81)90150-8. PMID: 6111013.
4: Kilpatrick GJ, Jenner P, Marsden CD. Specific [3H]piflutixol binding to CHAPS-solubilised rat striatal preparations involves dopamine D-2 but not D-1 binding sites. J Neurochem. 1986 Feb;46(2):413-21. doi: 10.1111/j.1471-4159.1986.tb12984.x. PMID: 3941314.
5: Hyttel J. Effect of piflutixol on turnover of catecholamines in mouse brain and rat corpus striatum. Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):449-57. doi: 10.1111/j.1600-0773.1977.tb02155.x. PMID: 579556.
6: Jenner P, Boyce S, Marsden CD. Receptor changes during chronic dopaminergic stimulation. J Neural Transm Suppl. 1988;27:161-75. doi: 10.1007/978-3-7091-8954-2_14. PMID: 2900291.
7: O'Boyle KM, Waddington JL. Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: association with increased non- specific binding of the D-1 ligand [3H]piflutixol. Eur J Pharmacol. 1984 Oct 1;105(1-2):171-4. doi: 10.1016/0014-2999(84)90663-0. PMID: 6149143.
8: Cross A, Rossor M. Dopamine D-1 and D-2 receptors in Huntington's disease. Eur J Pharmacol. 1983 Mar 25;88(2-3):223-9. doi: 10.1016/0014-2999(83)90009-2. PMID: 6221936.
9: O'Boyle KM, Waddington JL. Selective and stereospecific interactions of R-SK & F 38393 with [3H]piflutixol but not [3H]spiperone binding to striatal D1 and D2 dopamine receptors: comparisons with SCH 23390. Eur J Pharmacol. 1984 Mar 2;98(3-4):433-6. doi: 10.1016/0014-2999(84)90294-2. PMID: 6144559.
10: Klimek V, Nielsen M, Maj J. Repeated treatment with imipramine decreased the number of [3H]piflutixol binding sites in the rat striatum. Eur J Pharmacol. 1985 Feb 12;109(1):131-2. doi: 10.1016/0014-2999(85)90551-5. PMID: 2859994.
