Related CAS #
5636-92-0 (free base); 19803-62-4 (2HCl)
Synonym
Picloxydine dihydrochloride; Picloxydine 2HCl; NSC148548; NSC-148548; NSC 148548
IUPAC/Chemical Name
1,4-Piperazinedicarboxamidine, N,N''-bis((p-chlorophenyl)amidino)-, dihydrochloride
InChi Key
VJVSCTKGPDDOBN-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24Cl2N10.2ClH/c21-13-1-5-15(6-2-13)27-17(23)29-19(25)31-9-11-32(12-10-31)20(26)30-18(24)28-16-7-3-14(22)4-8-16;;/h1-8H,9-12H2,(H4,23,25,27,29)(H4,24,26,28,30);2*1H
SMILES Code
N=C(N1CCN(C(NC(NC2=CC=C(Cl)C=C2)=N)=N)CC1)NC(NC3=CC=C(Cl)C=C3)=N.[H]Cl.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
548.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Newcomb GM, McKellar GM, Rawal BD. An in vivo comparison of chlorhexidine and picloxydine mouthrinses: a possible association between chemical structure and antiplaque activity. J Periodontol. 1977 May;48(5):282-4. doi: 10.1902/jop.1977.48.5.282. PMID: 323454.
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6: Kanclerz P, Myers WG. Chlorhexidine and other alternatives for povidone- iodine in ophthalmic surgery: review of comparative studies. J Cataract Refract Surg. 2021 Jul 20. doi: 10.1097/j.jcrs.0000000000000754. Epub ahead of print. PMID: 34538779.
7: Obikili AG, Oji EO, Shonekan RO, Otti P. A double-blind comparison of picloxydine dihydrochloride (Vitabact eye drops) and sulfacetamide eye drops in the topical therapy of trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1988;65(3-4):119-32. English, French. PMID: 3274675.
8: Strakhovskaya MG, Lukashev EP, Korvatovskiy BN, Kholina EG, Seifullina NK, Knox PP, Paschenko VZ. The effect of some antiseptic drugs on the energy transfer in chromatophore photosynthetic membranes of purple non-sulfur bacteria Rhodobacter sphaeroides. Photosynth Res. 2021 Feb;147(2):197-209. doi: 10.1007/s11120-020-00807-x. Epub 2021 Jan 2. PMID: 33389445; PMCID: PMC7778420.
9: Stickler DJ, Thomas B. Antiseptic and antibiotic resistance in Gram-negative bacteria causing urinary tract infection. J Clin Pathol. 1980 Mar;33(3):288-96. doi: 10.1136/jcp.33.3.288. PMID: 6769972; PMCID: PMC1146054.
10: Stickler DJ, Thomas B, Chawla JC. Antiseptic and antibiotic resistance in gram-negative bacteria causing urinary tract infection in spinal cord injured patients. Paraplegia. 1981;19(1):50-8. doi: 10.1038/sc.1981.13. PMID: 7220061.
