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MedKoo Cat#: 465537 | Name: COB-172

Description:

WARNING: This product is for research use only, not for human or veterinary use.

COB-172 is a novel potent and selective Hα4β2 nAChR NAM.

Chemical Structure

COB-172
COB-172
CAS#2071683-99-1

Theoretical Analysis

MedKoo Cat#: 465537

Name: COB-172

CAS#: 2071683-99-1

Chemical Formula: C24H19NO

Exact Mass: 337.1467

Molecular Weight: 337.42

Elemental Analysis: C, 85.43; H, 5.68; N, 4.15; O, 4.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
COB-172; COB172; COB 172;
IUPAC/Chemical Name
N-(naphthalen-1-ylmethyl)-[1,1'-biphenyl]-2-carboxamide
InChi Key
IBWPQZLQBYNOPP-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H19NO/c26-24(23-16-7-6-15-22(23)19-9-2-1-3-10-19)25-17-20-13-8-12-18-11-4-5-14-21(18)20/h1-16H,17H2,(H,25,26)
SMILES Code
O=C(C1=C(C2=CC=CC=C2)C=CC=C1)NCC3=CC=CC4=C3C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Henderson BJ, Orac CM, Maciagiewicz I, Bergmeier SC, McKay DB. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1797-813. doi: 10.1016/j.bmcl.2011.11.051. Epub 2011 Nov 20. PMID: 22285942; PMCID: PMC3274641.