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MedKoo Cat#: 465529 | Name: CHU-128

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CHU-128 is a novel Non-peptide GLP-1R Agonist, adopting a unique binding mode with a more open receptor conformation at the extracellular face.

Chemical Structure

CHU-128
CHU-128
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465529

Name: CHU-128

CAS#: unknown

Chemical Formula: C47H47F2N11O5

Exact Mass: 883.3730

Molecular Weight: 883.96

Elemental Analysis: C, 63.86; H, 5.36; F, 4.30; N, 17.43; O, 9.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CHU-128; CHU128; CHU 128;
IUPAC/Chemical Name
3-((1S,2S)-1-(5-(2,2-dimethylmorpholino)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one
InChi Key
ZGWQLVGHYATWHT-RHCDABOCSA-N
InChi Code
InChI=1S/C47H47F2N11O5/c1-25-18-31(19-26(2)39(25)48)60-41(58-15-14-57(45(58)63)36-11-10-35-32(40(36)49)23-50-54(35)7)38-28(4)56(13-12-33(38)52-60)42(61)37-21-29-20-30(55-16-17-64-46(5,6)24-55)8-9-34(29)59(37)47(22-27(47)3)43-51-44(62)65-53-43/h8-11,14-15,18-21,23,27-28H,12-13,16-17,22,24H2,1-7H3,(H,51,53,62)/t27-,28-,47-/m0/s1
SMILES Code
O=C1NC([C@@]2(N3C(C(N4CCC5=NN(C6=CC(C)=C(F)C(C)=C6)C(N7C=CN(C8=C(F)C9=C(N(C)N=C9)C=C8)C7=O)=C5[C@@H]4C)=O)=CC%10=C3C=CC(N%11CC(C)(C)OCC%11)=C%10)[C@@H](C)C2)=NO1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 883.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D. Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol Cell. 2020 Nov 5;80(3):485-500.e7. doi: 10.1016/j.molcel.2020.09.020. Epub 2020 Oct 6. PMID: 33027691.