MedKoo Cat#: 465515 | Name: NJH-2-057
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NJH-2-057 is a novel covalent allosteric OTUB1-recruiting DUBTAG, robustly stabilizing DF508-CFTR in human cystic fibrosis bronchial epithelial cells in an OTUB1-dependent manner.

Chemical Structure

NJH-2-057
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465515

Name: NJH-2-057

CAS#: unknown

Chemical Formula: C43H44F2N6O8

Exact Mass: 810.3189

Molecular Weight: 810.86

Elemental Analysis: C, 63.69; H, 5.47; F, 4.69; N, 10.36; O, 15.78

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
NJH-2-057; NJH2-057; NJH 2-057; NJH-2057; NJH-2 057; NJH2057 NJH 2 057;
IUPAC/Chemical Name
N-(5-(3-(5-(4-acryloyl-2-oxopiperazin-1-yl)furan-2-yl)propanamido)pentyl)-3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzamide
InChi Key
GBRJFUUBXKOHMN-UHFFFAOYSA-N
InChi Code
InChI=1S/C43H44F2N6O8/c1-3-36(53)50-22-23-51(37(54)26-50)38-17-13-31(57-38)12-16-35(52)46-20-5-4-6-21-47-40(55)29-9-7-8-28(24-29)39-27(2)10-15-34(48-39)49-41(56)42(18-19-42)30-11-14-32-33(25-30)59-43(44,45)58-32/h3,7-11,13-15,17,24-25H,1,4-6,12,16,18-23,26H2,2H3,(H,46,52)(H,47,55)(H,48,49,56)
SMILES Code
O=C(NCCCCCNC(CCC1=CC=C(N2C(CN(C(C=C)=O)CC2)=O)O1)=O)C3=CC=CC(C4=NC(NC(C5(C6=CC=C(OC(F)(F)O7)C7=C6)CC5)=O)=CC=C4C)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 810.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL