MedKoo Cat#: 414927 | Name: Pumitepa

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pumitepa is a thiotepa derivative with potential antineoplastic alkylating activity.

Chemical Structure

Pumitepa
Pumitepa
CAS#42061-52-9

Theoretical Analysis

MedKoo Cat#: 414927

Name: Pumitepa

CAS#: 42061-52-9

Chemical Formula: C12H19N8OP

Exact Mass: 322.1419

Molecular Weight: 322.31

Elemental Analysis: C, 44.72; H, 5.94; N, 34.77; O, 4.96; P, 9.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pumitepa; BRN 1036986; BRN-1036986; BRN 103698
IUPAC/Chemical Name
P,P-Bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methylpurin-6-yl)phosphinic amide
InChi Key
KAEVHZSIYLATMK-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H19N8OP/c1-17(2)12-14-10-9(18(3)8-13-10)11(15-12)16-22(21,19-4-5-19)20-6-7-20/h8H,4-7H2,1-3H3,(H,14,15,16,21)
SMILES Code
O=P(N1CC1)(N2CC2)NC3=C4N(C)C=NC4=NC(N(C)C)=N3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 322.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Revazova IuA, Bratslavskiĭ VA. Izuchenie farmakokineticheskoĭ modifikatsii mutageneza [The pharmacokinetic modification of mutagenesis]. Vestn Ross Akad Med Nauk. 1993;(1):14-9. Russian. PMID: 7682117. 2: Seredenin SB, Bobkov IuG, Durnev AD, Dubovskaia OIu. Izuchenie mutagennykh i antimutagennykh svoĭstv bemitila [Mutagenic and antimutagenic properties of bemitil]. Biull Eksp Biol Med. 1986 Jul;102(7):76-9. Russian. PMID: 3089347. 3: Lazutka JR, Slapsyte G, Jarmalaite S, Lekevicius RK. In vitro interaction between two antineoplastic drugs--phopurinum and interferon alpha 2. Cancer Lett. 1989 Sep 15;47(1-2):53-6. doi: 10.1016/0304-3835(89)90176-6. PMID: 2636032. 4: Umbetkulova EK, Liubimova LS, Udovichenko AI, Ermakova GL, Martynova VA. K voprosu ob immunodepressivnom deĭstvii tsitostaticheskikh khimiopreparatov [Immunosuppressive effect of cytostatics]. Probl Gematol Pereliv Krovi. 1980 May;25(5):23-7. Russian. PMID: 6995972. 5: Vyborov AM, Romanenko GF. Sarkoma Kaposhi u dlitel'no prinimavsheĭ kortikosteroidy bol'noĭ [Kaposi's sarcoma in a female patient taking corticosteroids for a long time]. Vestn Dermatol Venerol. 1989;(1):48-9. Russian. PMID: 2718617. 6: Faĭnshteĭn FE, Kovaleva LG, Abakumov EM, Isaev VG, Vakhrusheva MV. Primenenie karminomitsina pri ostrykh leĭkozakh u vzroslykh [Use of carminomycin in adults with acute leukemia]. Klin Med (Mosk). 1984 Jan;62(1):67-71. Russian. PMID: 6584682. 7: Uryvaeva IV, Sokolov AS, Kalistratov SG, Delone GV. Zavisimost' tsitokineticheskikh éffektov alkiliruiushchikh protivoopukholevykh preparatov ot fazy kletochnogo tsikla gepatotsitov regeneriruiushcheĭ pecheni [The dependence of the cytokinetic effects of alkylating antitumor preparations on the phase of the hepatocyte cell cycle in regenerating liver]. Izv Akad Nauk SSSR Biol. 1991 Nov-Dec;(6):816-28. Russian. PMID: 1809781. 8: Revazova IuA, Bobrinev EV, Gvazava EA, Podol'naia MA. Pokazateli otsenki geneticheskikh povrezhdeniĭ, indutsirovannykh khimicheskimi soedineniiami. Otsenka induktsii khimicheskimi soedineniiami sestrinskikh khromatidnykh obmenov [Indices for assessing genetic damage induced by chemical compounds. Assessment of the induction of sister chromatid exchange by chemical compounds]. Genetika. 1982 Sep;18(9):1554-6. Russian. PMID: 6754530. 9: Lazutka IuS, Slapshite GV, Lekiavichius RK. Vliianie prirodnogo leĭkotsitarnogo chelovecheskogo interferona na kinetiku kletochnogo tsikla, chastotu sestrinskikh khromatidnykh obmenov i aberratsiĭ khromosom v limfotsitakh cheloveka, obrabotannykh fopurinom [Effect of natural human leukocyte interferon on cell cycle kinetics, the frequency of sister chromatid exchanges and chromosome aberrations in fopurin-treated human lymphocytes]. Tsitologiia. 1989 May;31(5):544-8. Russian. PMID: 2773063. 10: Suraĭkina TI, Bobrinoev EV, Skorobogatova SB, Zolotareva GN. Analiz morfometricheskikh priznakov mysheĭ dlia ucheta indutsirovannykh mutatsiĭ v zarodyshevykh kletkakh [Analysis of morphometric indices in mice for registration of induced mutations in germ cells]. Tsitol Genet. 1991 Jan- Feb;25(1):52-7. Russian. PMID: 1866785.