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MedKoo Cat#: 414921 | Name: Solasulfone Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Solasulfone Free Base is used in drug therapy of leprosy.

Chemical Structure

Solasulfone Free Base
Solasulfone Free Base
CAS#133-65-3 (free base)

Theoretical Analysis

MedKoo Cat#: 414921

Name: Solasulfone Free Base

CAS#: 133-65-3 (free base)

Chemical Formula: C30H28N2Na4O14S5

Exact Mass: 891.9735

Molecular Weight: 892.81

Elemental Analysis: C, 40.36; H, 3.16; N, 3.14; Na, 10.30; O, 25.09; S, 17.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
133-65-3 (free base); 144-75-2 (sodium)
Synonym
Solasulfone Free Base; Sulphetrone; Solapsone
IUPAC/Chemical Name
1,3-Propanedisulfonic acid, 1,1'-(sulfonylbis(p-phenyleneimino))bis(3-phenyl-, tetrasodium salt
InChi Key
WAGUNVVOQBKLDL-UHFFFAOYSA-J
InChi Code
InChI=1S/C30H32N2O14S5.4Na/c33-47(34,25-15-11-23(12-16-25)31-29(50(41,42)43)19-27(48(35,36)37)21-7-3-1-4-8-21)26-17-13-24(14-18-26)32-30(51(44,45)46)20-28(49(38,39)40)22-9-5-2-6-10-22;;;;/h1-18,27-32H,19-20H2,(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46);;;;/q;4*+1/p-4
SMILES Code
O=S(C1=CC=C(NC(S(=O)([O-])=O)CC(C2=CC=CC=C2)S(=O)([O-])=O)C=C1)(C3=CC=C(NC(S(=O)([O-])=O)CC(C4=CC=CC=C4)S(=O)([O-])=O)C=C3)=O.[Na+].[Na+].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 892.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Peters JH, Murray JF Jr, Gordon GR. The disposition of sulfoxone and solasulfone in leprosy patients. Lepr Rev. 1975 Sep;46(3):171-80. doi: 10.5935/0305-7518.19750018. PMID: 171530. 2: Naumov VZ, Iushchenko AA, Teplyĭ DL, Gorden MV, Lozovskaia MV. Sravnitel'noe izuchenie antioksidantnogo deĭstviia soliusul'fona i al'fa-tokoferola [Comparative study of the antioxidant effect of solasulfone and alpha- tocopherol]. Biull Eksp Biol Med. 2000 Jan;129(1):48-9. Russian. PMID: 10710627. 3: BROWNLEE G. Sulphetrone; therapeutics and toxicology. Lancet. 1948 Jul 24;2(6517):131-4. doi: 10.1016/s0140-6736(48)90494-2. PMID: 18870127. 4: MARANGONI P. Il sulfetrone [The sulfetron]. Farmaco Sci Tec. 1948 Jul- Aug;3(4):455. Italian. PMID: 18894870. 5: BROWNLEE G, GREEN AF, WOODBINE M. Sulphetrone, a chemotherapeutic agent for tuberculosis; pharmacology and chemotherapy. Br J Pharmacol Chemother. 1948 Mar;3(1):15-28. doi: 10.1111/j.1476-5381.1948.tb00348.x. PMID: 18904720; PMCID: PMC1509804. 6: MORLOCK HV, LIVINGSTONE R. Sulphetrone in pulmonary tuberculosis. Lancet. 1949 Dec 24;2(6591):1170. doi: 10.1016/s0140-6736(49)91827-9. PMID: 15397655. 7: MADIGAN DG. Treatment of tuberculosis with sulphetrone. Lancet. 1948 Jul 31;2(6518):174-9. doi: 10.1016/s0140-6736(48)90536-4. PMID: 18870135. 8: RELWICZ AL. Some experiments with injected sulphetrone. Lepr Rev. 1950 Jan- Apr;21(1):30-4. doi: 10.5935/0305-7518.19500004. PMID: 24537260. 9: WEISS W, BOGEN E. The clinical toxicity of sulphetrone. Am Rev Tuberc. 1950 Aug;62(2):160-9. doi: 10.1164/art.1950.62.2.160. PMID: 15432878. 10: CLAY MG, CLAY AC. Chemotherapy of tuberculosis with sulphetrone. Lancet. 1948 Jul 31;2(6518):180-2. doi: 10.1016/s0140-6736(48)90537-6. PMID: 18870136.

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