Synonym
Midaglizole dihydrochloride; Midaglizole 2HCl
IUPAC/Chemical Name
Pyridine, 2-(2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl)-,dihydrochloride
InChi Key
PAKRIOPMNVCTCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17N3.2ClH/c1-2-6-13(7-3-1)14(12-16-18-10-11-19-16)15-8-4-5-9-17-15;;/h1-9,14H,10-12H2,(H,18,19);2*1H
SMILES Code
Cl.Cl.C(C(c1ccccc1)c2ccccn2)C3=NCCN3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Yamada Y, Kono N, Hanafusa T, Mineo I, Namba M, Itoh H, Kiyokawa H, Kawachi M, Yamasaki T, Tarui S. Exaggerated insulin secretory response in patients with insulinomas to midaglizole, a drug with alpha 2-adrenergic blocking activity. Clin Endocrinol (Oxf). 1988 Jul;29(1):29-34. doi: 10.1111/j.1365-2265.1988.tb00246.x. PMID: 2854759.
2. Sakai H, Dobashi K, Iizuka K, Nakazawa T. Protective effect of an alpha 2-adrenoceptor antagonist, midaglizole, against allergen-provoked late asthmatic responses. J Asthma. 1995;32(3):221-6. doi: 10.3109/02770909509089511. PMID: 7759462.
3. Proks P, Treinies I, Mest HJ, Trapp S. Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. doi: 10.1016/s0014-2999(02)02234-3. PMID: 12323381.
