VU-6008667, an analogue of VU0483253, is an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. VU6008667 prevented acquisition of oxycodone self-administration behavior. VU6008667 had minimal effects on naloxone-precipitated withdrawal. After acute administration, VU6008667 did not inhibit sucrose self-administration and, when given chronically, delayed but did not prevent acquisition of sucrose maintained self-administration.
MedKoo Cat#: 465495
Name: VU-6008667
CAS#: 2092923-21-0
Chemical Formula: C24H17ClF2N2O2
Exact Mass: 438.0947
Molecular Weight: 438.86
Elemental Analysis: C, 65.68; H, 3.90; Cl, 8.08; F, 8.66; N, 6.38; O, 7.29
The following data is based on the product molecular weight 438.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
