Synonym
SUN13837; SUN 13837; SUN-13837;
IUPAC/Chemical Name
2-((5-amino-4,6-dimethylpyrimidin-2-yl)oxy)-N-(1-benzylpiperidin-4-yl)-N-methylacetamide
InChi Key
UFFJZHVXSNLCEE-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H29N5O2/c1-15-20(22)16(2)24-21(23-15)28-14-19(27)25(3)18-9-11-26(12-10-18)13-17-7-5-4-6-8-17/h4-8,18H,9-14,22H2,1-3H3
SMILES Code
CN(C(COC1=NC(C)=C(N)C(C)=N1)=O)C(CC2)CCN2CC3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Imagama S, Ogino R, Ueno S, Murayama N, Takemoto N, Shimmyo Y, Kadoshima T, Tamura S, Kuroda M, Matsuyama Y, Kadomatsu K, Morita Y, Inoue T, Ishiguro N. Systemic treatment with a novel basic fibroblast growth factor mimic small- molecule compound boosts functional recovery after spinal cord injury. PLoS One. 2020 Jul 17;15(7):e0236050. doi: 10.1371/journal.pone.0236050. PMID: 32678832; PMCID: PMC7367485.
2: Sakai H, Inoue H, Murata K, Toba T, Shimmyo Y, Narii N, Ueno SY, Igawa Y, Takemoto N. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562. doi: 10.1016/j.bmc.2020.115562. Epub 2020 May 24. PMID: 32616184.
3: Sakai H, Inoue H, Toba T, Murata K, Narii N, Shimmyo Y, Igawa Y, Matsumoto T, Takemoto N. Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2332-2337. doi: 10.1016/j.bmcl.2019.06.016. Epub 2019 Jun 18. PMID: 31255484.
4: Witiw CD, Fehlings MG. Acute Spinal Cord Injury. J Spinal Disord Tech. 2015 Jul;28(6):202-10. doi: 10.1097/BSD.0000000000000287. PMID: 26098670.
