MedKoo Cat#: 414917 | Name: Phenyltoloxamine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenyltoloxamine Free Base is an antihistamine with sedative and analgesic effects. It is available in combination with other drugs such as paracetamol.

Chemical Structure

Phenyltoloxamine Free Base
Phenyltoloxamine Free Base
CAS#92-12-6 (free base)

Theoretical Analysis

MedKoo Cat#: 414917

Name: Phenyltoloxamine Free Base

CAS#: 92-12-6 (free base)

Chemical Formula: C17H21NO

Exact Mass: 255.1623

Molecular Weight: 255.36

Elemental Analysis: C, 79.96; H, 8.29; N, 5.49; O, 6.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
92-12-6 (free base); 1176-08-5 (citrate)
Synonym
Phenyltoloxamine Free Base; C 5581H; C5581H; C-5581H
IUPAC/Chemical Name
Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-
InChi Key
IZRPKIZLIFYYKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H21NO/c1-18(2)12-13-19-17-11-7-6-10-16(17)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
SMILES Code
CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Phenyltoloxamine. 2017 Jan 16. PMID: 31644096. 2: PHENYLTOLOXAMINE citrate. J Am Med Assoc. 1957 Feb 2;163(5):357. PMID: 13385164. 3: El-Kommos ME, Emara KM. Determination of phenyltoloxamine salicylamide, caffeine, paracetamol, codeine and phenacetin by HPLC. Talanta. 1989 Jun;36(6):678-9. doi: 10.1016/0039-9140(89)80263-2. PMID: 18964780. 4: Forbes JA, Barkaszi BA, Ragland RN, Hankle JJ. Analgesic effect of acetaminophen, phenyltoloxamine and their combination in postoperative oral surgery pain. Pharmacotherapy. 1984 Jul-Aug;4(4):221-6. doi: 10.1002/j.1875-9114.1984.tb03362.x. PMID: 6483639. 5: CRONK GA, NAUMANN DE. Phenyltoloxamine--dosage, toxicity, and clinical application. N Y State J Med. 1955 May 15;55(10):1465-7. PMID: 14370508. 6: Rumore MM, Schlichting DA. Analgesic effects of antihistaminics. Life Sci. 1985 Feb 4;36(5):403-16. doi: 10.1016/0024-3205(85)90252-8. PMID: 2578597. 7: Peng Y, Dong H, Welsh WJ. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. doi: 10.1021/acs.jcim.8b00521. Epub 2018 Dec 14. PMID: 30497261. 8: Dotti A. Sperimentazione clinica dell'azione tussifuga dell'associazione codeina plus feniltoloxamina [Clinical trial of the antitussive action of an association of codeine plus phenyltoloxamine]. G Ital Mal Torace. 1970 May- Jun;24(3):147-57. Italian. PMID: 5492933. 9: Falliers CJ, Redding MA, Katsampes CP. Inhibition of cutaneous and mucosal allergy with phenyltoloxamine. Ann Allergy. 1978 Sep;41(3):140-4. PMID: 28684. 10: OGDEN HD. DEXAMETHASONE-PHENYLTOLOXAMINE IN BRONCHIAL ASTHMA. Med Times. 1963 Oct;91:1015-8. PMID: 14047884.