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MedKoo Cat#: 414906 | Name: Phenazepam HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phenazepam HCl is a benzodiazepine drug, which was developed in the Soviet Union in 1975, and now produced in Russia and some CIS countries. Phenazepam is used in the treatment of various mental disorders such as psychiatric schizophrenia and anxiety. It can be used as a premedication before surgery as it augments the effects of anesthetics.

Chemical Structure

Phenazepam HCl
Phenazepam HCl
CAS#103380-41-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 414906

Name: Phenazepam HCl

CAS#: 103380-41-2 (HCl)

Chemical Formula: C15H11BrCl2N2O

Exact Mass:

Molecular Weight: 386.07

Elemental Analysis: C, 46.67; H, 2.87; Br, 20.70; Cl, 18.36; N, 7.26; O, 4.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
103380-41-2 (HCl); 51753-57-2 (Free Base)
Synonym
Phenazepam hydrochloride; Phenazepam HCl; KC3757; KC 3757; KC-3757
IUPAC/Chemical Name
2H-1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-, monohydrochloride
InChi Key
JNTFJOZXGQFDKI-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10BrClN2O.ClH/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17;/h1-7H,8H2,(H,19,20);1H
SMILES Code
O=C1NC2=CC=C(Br)C=C2C(C3=CC=CC=C3Cl)=NC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Moosmann B, Auwärter V. Designer Benzodiazepines: Another Class of New Psychoactive Substances. Handb Exp Pharmacol. 2018 Oct 27. doi: 10.1007/164_2018_154. [Epub ahead of print] PubMed PMID: 30367253. 2: Bäckberg M, Pettersson Bergstrand M, Beck O, Helander A. Occurrence and time course of NPS benzodiazepines in Sweden - results from intoxication cases in the STRIDA project. Clin Toxicol (Phila). 2018 Oct 22:1-10. doi: 10.1080/15563650.2018.1506130. [Epub ahead of print] PubMed PMID: 30348014. 3: Neznamov GG, Bochkarev VK. [Subjective evaluation of the effect of single test doses of phenazepam and placebo in patients with anxiety disorders: a relationship with objective pharmaco-electroencephalography characteristics]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(9):53-60. doi: 10.17116/jnevro201811809153. Russian. PubMed PMID: 30335073. 4: Zastrozhin MS, Antonenko AP, Nesterenko EV, Seyfullaeva LI, Mustafina VR, Esakova AP, Grishina EA, Sorokin AS, Skryabin VY, Savchenko LM, Bryun EA, Sychev DA. Effects of CYP2C19*17 polymorphisms on the efficacy and safety of bromodigyrochlorophenylbenzodiazepine in patients with anxiety disorder and comorbid alcohol use disorder. Drug Metab Pers Ther. 2018 Dec 19;33(4):187-194. doi: 10.1515/dmpt-2018-0019. PubMed PMID: 30325732. 5: Ivashchenko DV, Rudik AV, Poloznikov AA, Nikulin SV, Smirnov VV, Tonevitsky AG, Bryun EA, Sychev DA. Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies. Drug Metab Pers Ther. 2018 Jun 27;33(2):65-73. doi: 10.1515/dmpt-2017-0036. PubMed PMID: 29727298. 6: Manchester KR, Maskell PD, Waters L. Experimental versus theoretical log D(7.4) , pK(a) and plasma protein binding values for benzodiazepines appearing as new psychoactive substances. Drug Test Anal. 2018 Mar 26. doi: 10.1002/dta.2387. [Epub ahead of print] PubMed PMID: 29582576. 7: Nenasteva AY. [Phenazepam: to the question of the efficacy and safety of benzodiazepine derivatives]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):156-161. doi: 10.17116/jnevro2017117121156-160. Review. Russian. PubMed PMID: 29376999. 8: Afandiyev I, Azizov V. [POISONING BY PSYCHOPHARMACOLOGICAL DRUGS IN AZERBAIJAN: THE RESULTS OF 8-YEAR PROSPECTIVE OBSERVATION]. Georgian Med News. 2017 Nov;(272):138-144. Russian. PubMed PMID: 29227273. 9: Snigirov S, Sylantyev S. GABA(A) receptors activate fish feeding behaviour via two distinct functional pathways. J Exp Biol. 2018 Feb 7;221(Pt 3). pii: jeb170514. doi: 10.1242/jeb.170514. PubMed PMID: 29191862; PubMed Central PMCID: PMC5818037. 10: Strand MC, Mørland J, Slørdal L, Riedel B, Innerdal C, Aamo T, Mathisrud G, Vindenes V. Conversion factors for assessment of driving impairment after exposure to multiple benzodiazepines/z-hypnotics or opioids. Forensic Sci Int. 2017 Dec;281:29-36. doi: 10.1016/j.forsciint.2017.10.022. Epub 2017 Oct 20. PubMed PMID: 29101905. 11: Švidrnoch M, Boráňová B, Tomková J, Ondra P, Maier V. Simultaneous determination of designer benzodiazepines in human serum using non-aqueous capillary electrophoresis - Tandem mass spectrometry with successive multiple ionic - Polymer layer coated capillary. Talanta. 2018 Jan 1;176:69-76. doi: 10.1016/j.talanta.2017.08.010. Epub 2017 Aug 3. PubMed PMID: 28917807. 12: Meng L, Zhu B, Zheng K, Fu S. Ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction for the determination of 4 designer benzodiazepines in urine samples by gas chromatography-triple quadrupole mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 15;1053:9-15. doi: 10.1016/j.jchromb.2017.04.008. Epub 2017 Apr 4. PubMed PMID: 28399467. 13: Tomková J, Švidrnoch M, Maier V, Ondra P. Analysis of selected designer benzodiazepines by ultra high performance liquid chromatography with high-resolution time-of-flight mass spectrometry and the estimation of their partition coefficients by micellar electrokinetic chromatography. J Sep Sci. 2017 May;40(9):2037-2044. doi: 10.1002/jssc.201700069. Epub 2017 Apr 10. PubMed PMID: 28266783. 14: Sudakov SK, Nazarova GA, Alekseeva EV. New Experimental Model of Rat Risk Behavior. Effects of Nicotine and Phenazepam. Bull Exp Biol Med. 2017 Jan;162(3):409-411. doi: 10.1007/s10517-017-3627-z. Epub 2017 Jan 14. PubMed PMID: 28091916. 15: Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V. Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam. J Mass Spectrom. 2016 Nov;51(11):1080-1089. doi: 10.1002/jms.3840. PubMed PMID: 27535017. 16: Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY. Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clin Toxicol (Phila). 2017 Jan;55(1):71-72. doi: 10.1080/15563650.2016.1240806. Epub 2016 Oct 13. PubMed PMID: 27736261. 17: Mata DC. Stability of 26 Sedative Hypnotics in Six Toxicological Matrices at Different Storage Conditions. J Anal Toxicol. 2016 Oct;40(8):663-668. Epub 2016 Aug 22. PubMed PMID: 27550995. 18: Cha HJ, Lee KW, Eom JH, Kim YH, Shin J, Yun J, Han K, Kim HS. 5-(2-Aminopropyl)benzofuran and phenazepam demonstrate the possibility of dependence by increasing dopamine levels in the brain. Pharmacol Biochem Behav. 2016 Oct;149:17-22. doi: 10.1016/j.pbb.2016.08.002. Epub 2016 Aug 6. PubMed PMID: 27502147. 19: Kundashev UK, Salenko YA, Morozov IS, Zurdinov AZ, Barchukov VG. [EFFECT OF MEDIATOR-TYPE DRUGS ON HUMAN PSYCHOPHYSIOLOGICAL STATUS DURING MODEL OPERATOR ACTIVITY]. Eksp Klin Farmakol. 2016;79(2):9-13. Russian. PubMed PMID: 27416676. 20: Lim WJ, Yap AT, Mangudi M, Koh HB, Tang AS, Chan KB. Detection of phenazepam in illicitly manufactured Erimin 5 tablets. Drug Test Anal. 2017 Feb;9(2):293-305. doi: 10.1002/dta.1981. Epub 2016 Jul 8. PubMed PMID: 27390251.

View History

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