AM10257 is a CB2 antagonist. AM10257 shows a high affinity (inhibition constant [Ki]=0.08 nM for CB2), as determined by radioligand competition assays, against [3H]-CP55,940 (Kd = 0.86 nM) Importantly, the binding affinity of the crystallized CB2 construct for AM10257 is still in the sub-nanomolar range (Ki = 0.61 nM). In assays assessing the regulation of adenylyl cyclase and b-arrestin2 recruitment,AM10257 acted as an inverse agonist and competitive antagonist at CB2
MedKoo Cat#: 465484
Name: AM10257
CAS#: 2316841-32-2
Chemical Formula: C26H35N3O2
Exact Mass: 421.2729
Molecular Weight: 421.59
Elemental Analysis: C, 74.07; H, 8.37; N, 9.97; O, 7.59
The following data is based on the product molecular weight 421.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
