AZ14145845 is a Type I1/2 Dual Mer/Axl Kinase Inhibitor. AZ14145845 showed dose-dependent in vivo efficacy and targeted engagement in Mer- and Axl-dependent efficacy models using two structurally differentiated and selective dual Mer/Axl inhibitors. Additionally, in vivo efficacy was observed in a preclinical MC38 immunooncology model in combination with anti-PD1 antibodies and ionizing radiation.
MedKoo Cat#: 465474
Name: AZ14145845
CAS#: unknown
Chemical Formula: C32H35N9O
Exact Mass: 561.2965
Molecular Weight: 561.69
Elemental Analysis: C, 68.43; H, 6.28; N, 22.44; O, 2.85
The following data is based on the product molecular weight 561.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
