PSMA-DA1 is a straight-chain PSMA-targeting radioligand, and is a useful ligand for making 225Ac-Labeled complex Targeting Prostate-Specific Membrane Antigen. [111In]In-PSMA−DA1 demonstrated significantly greater tumor uptake and retention than a corresponding non-ALB-conjugated compound. In mice, single-photon emission computed tomography performed with [111In]In-PSMA−DA1 produced clear tumor images, and the administration of [90Y]Y-PSMA−DA1 or [225Ac]Ac-PSMA−DA1 inhibited tumor growth. [225Ac]Ac-PSMA−DA1 had antitumor effects in mice at a lower radioactivity level than [225Ac]Ac-PSMA-617, which has been reported to be clinically useful.
MedKoo Cat#: 465472
Name: PSMA-DA1
CAS#: unknown
Chemical Formula: C50H76IN9O20
Exact Mass: 1249.4251
Molecular Weight: 1250.11
Elemental Analysis: C, 48.04; H, 6.13; I, 10.15; N, 10.08; O, 25.60
The following data is based on the product molecular weight 1,250.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
