ARN19689 is a Non-Covalent N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitor for Oral Administration. ARN19689 was found to inhibit human NAAA in the low nanomolar range (IC50 = 42 nM) with a non-covalent mechanism of action. In light of its favorable biochemical, in vitro and in vivo drug-like profile, sulfonamide 50 could be regarded as a promising pharmacological tool to be further investigated in the field of inflammatory conditions.
MedKoo Cat#: 465459
Name: ARN19689
CAS#: unknown
Chemical Formula: C19H27N5O4S
Exact Mass: 421.1784
Molecular Weight: 421.52
Elemental Analysis: C, 54.14; H, 6.46; N, 16.62; O, 15.18; S, 7.61
The following data is based on the product molecular weight 421.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
