MedKoo Cat#: 414863 | Name: Perivine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perivine is an alkaloid compound which may resolve the instability of the retinoblastoma-associated proteins (RbAp48) complex and thus be used in Alzheimer's disease therapy.

Chemical Structure

Perivine
Perivine
CAS#2673-40-7

Theoretical Analysis

MedKoo Cat#: 414863

Name: Perivine

CAS#: 2673-40-7

Chemical Formula: C20H22N2O3

Exact Mass: 338.1630

Molecular Weight: 338.41

Elemental Analysis: C, 70.99; H, 6.55; N, 8.28; O, 14.18

Price and Availability

Size Price Availability Quantity
1mg USD 340.00 2 Weeks
2mg USD 540.00 2 Weeks
5mg USD 850.00 2 Weeks
10mg USD 1,250.00 2 Weeks
25mg USD 1,700.00 2 Weeks
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Related CAS #
No Data
Synonym
Perivine; BRN0046952; BRN-0046952; BRN 0046952
IUPAC/Chemical Name
methyl (2S,6R,14S,E)-5-ethylidene-8-oxo-2,3,4,5,6,7,8,9-octahydro-1H-2,6-methanoazecino[5,4-b]indole-14-carboxylate
InChi Key
NKTORRNHKYVXSU-XXMLWKDOSA-N
InChi Code
InChI=1S/C20H22N2O3/c1-3-11-10-21-16-8-14-12-6-4-5-7-15(12)22-19(14)17(23)9-13(11)18(16)20(24)25-2/h3-7,13,16,18,21-22H,8-10H2,1-2H3/b11-3-/t13-,16-,18-/m0/s1
SMILES Code
COC([C@@H]1[C@@H]2Cc(c(C(C[C@H]1/C(CN2)=C\C)=O)[nH]3)c4c3cccc4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sim DS, Tang SY, Low YY, Lim SH, Kam TS. Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa. Phytochemistry. 2022 Nov;203:113384. doi: 10.1016/j.phytochem.2022.113384. Epub 2022 Aug 23. PMID: 36007666. 2: Levac D, Flores PC, De Luca V. Molecular and biochemical characterization of Catharanthus roseus perivine-Nβ-methyltransferase. Phytochemistry. 2022 Sep;201:113266. doi: 10.1016/j.phytochem.2022.113266. Epub 2022 Jun 6. PMID: 35671807. 3: Tiong SH, Looi CY, Arya A, Wong WF, Hazni H, Mustafa MR, Awang K. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae). Fitoterapia. 2015 Apr;102:182-8. doi: 10.1016/j.fitote.2015.01.019. Epub 2015 Feb 7. PMID: 25665941. 4: Huang HJ, Lee CC, Chen CY. Lead discovery for Alzheimer's disease related target protein RbAp48 from traditional Chinese medicine. Biomed Res Int. 2014;2014:764946. doi: 10.1155/2014/764946. Epub 2014 Jun 2. PMID: 25165715; PMCID: PMC4086058. 5: van der Heijden R, Louwe CL, Verhey ER, Harkes PA, Verpoorte R. Characterization of a Suspension Culture of Tabernaemontana elegans on Growth, Nutrient Uptake, and Accumulation of Indole Alkaloids*. Planta Med. 1989 Apr;55(2):158-62. doi: 10.1055/s-2006-961912. PMID: 17262332. 6: van der Heijden R, Hermans-Lokkerbol A, de Kool LP, Lamping PJ, Harkes PA, Verpoorte R. Accumulation of indole alkaloids in a suspension culture of Tabernaemontana divaricata. Planta Med. 1988 Oct;54(5):393-7. doi: 10.1055/s-2006-962479. PMID: 17265301. 7: Perera P, Kanjanapothy D, Sandberg F, Verpoorte R. Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids. J Ethnopharmacol. 1985 May;13(2):165-73. doi: 10.1016/0378-8741(85)90004-2. PMID: 4021514. 8: Perera P, Samuelsson G, van Beek TA, Verpoorte R. Tertiary indole alkaloids from leaves of Tabernaemontana dichotoma. Planta Med. 1983 Mar;47(3):148-50. doi: 10.1055/s-2007-969974. PMID: 17404903. 9: Feng XZ, Kan C, Potier P, Kan SK, Lounasmaa M. Monomeric Indole Alkaloids from Ervatamia hainanensis. Planta Med. 1982 Apr;44(4):212-4. doi: 10.1055/s-2007-971449. PMID: 17402121. 10: Rojas Hernández NM. Evaluación de la actividad antimicrobiana de alcaloides indólicos [Evaluation of antimicrobial activity of indol alkaloids]. Rev Cubana Med Trop. 1979 Sep-Dec;31(3):199-204. Spanish. PMID: 399043. 11: Reda F. Distribution and accumulation of alkaloids in Catharanthus roseus G. Don during development. Pharmazie. 1978 Apr;33(4):233-4. PMID: 674322. 12: Kingston DG, Gerhart BB, Ionescu F, Mangino MM, Sami SM. Plant anticancer agents V: new bisindole alkaloids from Tabernaemontana johnstonii stem bark. J Pharm Sci. 1978 Feb;67(2):249-51. doi: 10.1002/jps.2600670232. PMID: 621649. 13: Kingston DG, Li BT, Ionescu F. Plant anticancer agents III: Isolation of indole and bisindole alkaloids from Tabernaemontana holstii roots. J Pharm Sci. 1977 Aug;66(8):1135-8. doi: 10.1002/jps.2600660821. PMID: 561182. 14: Cava MP, Talapatra SK, Weisbach JA, Douglas B, Raffauf RF, Beal JL. Gabunine: a natural dimeric indole derived from perivine. Tetrahedron Lett. 1965 Apr;(14):931-5. doi: 10.1016/s0040-4039(01)99501-2. PMID: 5841970. 15: FARNSWORTH NR, LOUB WD, BLOMSTER RN. STUDIES ON CATHARANTHUS LANCEUS (VINCA LANCEA). I. ISOLATION OF LEUROSINE, PERIVINE, AND YOHIMBINE. J Pharm Sci. 1963 Nov;52:1114. doi: 10.1002/jps.2600521126. PMID: 14079649. 16: SVOBODA GH. A note on several new alkaloids from Vinca rosea Linn. I. Leurosine, virosine, perivine. J Am Pharm Assoc Am Pharm Assoc. 1958 Nov;47(11):834. doi: 10.1002/jps.3030471121. PMID: 13587332.