Synonym
Penimocycline; Penimociclina; Penimocyclinum
IUPAC/Chemical Name
6-(((((((4-(Dimethylamino)-1,4alpha,4aalpha,5,5aalpha,6beta,11,12aalpha-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl)carbonyl)amino)methyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
InChi Key
ZVVMCQBZCQRRME-UHFFFAOYSA-N
InChi Code
InChI=1S/C39H43N5O12S/c1-37(2)29(36(53)54)44-34(52)25(35(44)57-37)42-33(51)24(16-10-7-6-8-11-16)40-15-41-32(50)23-28(47)26(43(4)5)19-14-18-22(30(48)39(19,56)31(23)49)27(46)21-17(38(18,3)55)12-9-13-20(21)45/h6-13,18-19,24-26,29,35,40,45,47-48,55-56H,14-15H2,1-5H3,(H,41,50)(H,42,51)(H,53,54)
SMILES Code
O=C(C(C(C)(C)SC1C2NC(C(NCNC(C(C3=O)=C(O)C(N(C)C)C4CC5C(C)(O)C6=C(C(C5=C(O)C43O)=O)C(O)=CC=C6)=O)C7=CC=CC=C7)=O)N1C2=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
805.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ren G, Chen H, Zhang M, Yang N, Yang H, Xu C, Li J, Ning C, Song Z, Zhou S, Bian Y, Lu Y, Li N, Zhang Y, Chen X, Zhao D. Pharmacokinetics, tissue distribution and excretion study of Oroxylin A, Oroxylin A 7-O-glucuronide and Oroxylin A sodium sulfonate in rats after administration of Oroxylin A. Fitoterapia. 2020 Apr;142:104480. doi: 10.1016/j.fitote.2020.104480. Epub 2020 Jan 9. PMID: 31927013.
2: Chevalier G, Bollet C, Rohrbach P, Risse C, Caude M, Rosset R. Etude de la pénimocycline par chromatographie en phase liquide à haute performance [High- performance liquid chromatography of penimocycline (author's transl)]. J Chromatogr. 1976 Sep 15;124(2):343-9. French. doi: 10.1016/s0021-9673(00)89750-2. PMID: 965467.
3: Zhai Y, Gan L, Huang S, Xing Q, Zhou X, Wang L, Feng C, Chen L, Li T. Therapeutic effect of ultrasound interventional perirenal catheter-assisted early peripancreatic lavage of protease inhibitor on severe acute pancreatitis in miniature pigs. Pancreatology. 2019 Jan;19(1):158-162. doi: 10.1016/j.pan.2018.12.002. Epub 2018 Dec 5. PMID: 30551934.
4: Stieger-Vanegas SM, Cebra CK. Contrast-enhanced computed tomography of the gastrointestinal tract in clinically normal alpacas and llamas. J Am Vet Med Assoc. 2013 Jan 15;242(2):254-60. doi: 10.2460/javma.242.2.254. PMID: 23276105.
5: Monges H, Remacle JP. Essais cliniques de l'Intraxium en pathologie digestive [Clinical trials of Intraxium in digestive pathology]. Sem Hop Ther. 1975 Jan;51(1):19-21. French. PMID: 1162368.
6: Berthaux P. Traitement des infections en gériatrie. Efficacité de l'intraxium [Treatment of geriatric infections. Effectiveness of Intraxium]. Sem Hop Ther. 1975 Dec;51(10):543-6. French. PMID: 1209266.
