Metiapine | CAS# 5800-19-1 | Antipsychotic

MedKoo Cat#: 577349 | Name: Metiapine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metiapine is a typical antipsychotic medication of the dibenzothiazepine group.

Chemical Structure

Metiapine

CAS#5800-19-1

Theoretical Analysis

MedKoo Cat#: 577349

Name: Metiapine

CAS#: 5800-19-1

Chemical Formula: C19H21N3S

Exact Mass: 323.1456

Molecular Weight: 323.46

Elemental Analysis: C, 70.55; H, 6.54; N, 12.99; S, 9.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Metiapine

IUPAC/Chemical Name

Dibenzo(b,f)(1,4)thiazepine, 2-methyl-11-(4-methyl-1-piperazinyl)-

InChi Key

IOEPXYJOHIZYGQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H21N3S/c1-14-7-8-17-15(13-14)19(22-11-9-21(2)10-12-22)20-16-5-3-4-6-18(16)23-17/h3-8,13H,9-12H2,1-2H3

SMILES Code

CN1CCN(CC1)C2=Nc3ccccc3Sc4ccc(C)cc24

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Toxicity Data: Mouse - LD50, Intraperitoneal (320mg/kg) - Effects: General Anesthetic, Somnolence, Convulsions or Effect on Seizure Threshold. Mouse - LD50, Oral (680mg/kg) - Effects: None Reported. Rat - LD50, Intraperitoneal (487mg/kg) - Effects: General Anesthetic, Somnolence, Convulsions or Effect on Seizure Threshold. Rat - LD50, Oral (934mg/kg) - Effects: None Reported. Source: Toxicology and Applied Pharmacology. Vol. 25, Pg. 220, 1973. Toxicology and Applied Pharmacology. Vol. 22, Pg. 334, 1972.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 323.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Zare M, Bazrafshan A. Chlorpromazine versus metiapine for schizophrenia. Cochrane Database Syst Rev. 2017 Mar 25;3(3):CD011655. doi: 10.1002/14651858.CD011655.pub2. PMID: 28349512; PMCID: PMC6464499. 2. Steinbook RM, Goldstein BJ, Brauzer B, Jacobson AF, Moreno SS. Metiapine: a double-blind comparison with chlorpromazine in acute schizophrenic patients. J Clin Pharmacol. 1975 Oct;15(10):700-4. doi: 10.1002/j.1552-4604.1975.tb05923.x. PMID: 1102569. 3. Gallant DM, Bishop MP, Guerrero-Figueroa R. Metiapine: a new antipsychotic agent. Curr Ther Res Clin Exp. 1970 Dec;12(12):794-7. PMID: 4994684.