MedKoo Cat#: 465450 | Name: LQN-00346

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LQN-00346 is a novel BAM complex inhibitor, interferring with BamA-related processes and affect folding and insertion of OMPs. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

LQN-00346
LQN-00346
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465450

Name: LQN-00346

CAS#: unknown

Chemical Formula: C20H22N6

Exact Mass: 346.1906

Molecular Weight: 346.44

Elemental Analysis: C, 69.34; H, 6.40; N, 24.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LQN-00346; LQN00346; LQN 00346; BAM Complex Inhibitor 14;
IUPAC/Chemical Name
2-(2-aminopyridin-4-yl)-N4-benzyl-5,6,7,8-tetrahydroquinazoline-4,6-diamine
InChi Key
LZWDBHHJZGBLLQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H22N6/c21-15-6-7-17-16(11-15)20(24-12-13-4-2-1-3-5-13)26-19(25-17)14-8-9-23-18(22)10-14/h1-5,8-10,15H,6-7,11-12,21H2,(H2,22,23)(H,24,25,26)
SMILES Code
NC1CC2=C(NCC3=CC=CC=C3)N=C(C4=CC(N)=NC=C4)N=C2CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 346.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Steenhuis M, Corona F, Ten Hagen-Jongman CM, Vollmer W, Lambin D, Selhorst P, Klaassen H, Versele M, Chaltin P, Luirink J. Combining Cell Envelope Stress Reporter Assays in a Screening Approach to Identify BAM Complex Inhibitors. ACS Infect Dis. 2021 Aug 13;7(8):2250-2263. doi: 10.1021/acsinfecdis.0c00728. Epub 2021 Jun 14. PMID: 34125508; PMCID: PMC8369490.