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MedKoo Cat#: 414829 | Name: Peimisine Free Base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peimisine Free Base non-competitively antagonizes tracheal smooth muscle muscarinic M receptor and inhibits smooth muscle contraction caused by Ach.

Chemical Structure

Peimisine Free Base
Peimisine Free Base
CAS#19773-24-1 (free base)

Theoretical Analysis

MedKoo Cat#: 414829

Name: Peimisine Free Base

CAS#: 19773-24-1 (free base)

Chemical Formula: C27H40NO3

Exact Mass: 426.3008

Molecular Weight: 426.62

Elemental Analysis: C, 76.02; H, 9.45; N, 3.28; O, 11.25

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 850.00 2 Weeks
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Related CAS #
19773-24-1 (free base); 900498-44-4 (HCl)
Synonym
Peimisine Free Base
IUPAC/Chemical Name
Veratraman-6(5H)-one, 17,23-epoxy-3-hydroxy-, (3beta)-
InChi Key
JDENSRFDORZPPH-FFUJEENUSA-N
InChi Code
InChI=1S/C27H40NO3/c1-14-9-24-25(28-13-14)16(3)27(31-24)8-6-18-19(15(27)2)11-21-20(18)12-23(30)22-10-17(29)5-7-26(21,22)4/h14,16-18,20-21,24-25,28-29H,5-13H2,1-4H3/t14-,16+,17-,18+,20-,21-,24?,25-,26+,27-/m0/s1
SMILES Code
C[C@H]([C@]1(C2C[C@H](C)CN1)[H])[C@]3(O2)CC[C@@]4([H])[C@]5([H])CC(=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC4=C3C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 426.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Epub 2023 Dec 23. PMID: 38145860. 4: Li Y, Yang X, Han J, Bai B, Li Y, Shang C, Li S, Xiu Z, Liu Z, Ge C, Zhu G, Jin N, Fang J, Li Y, Li X, Zhu Y. Peimisine ameliorates DSS-induced colitis by suppressing Jak-Stat activation and alleviating gut microbiota dysbiosis in mice. J Pharm Pharmacol. 2024 May 3;76(5):545-558. doi: 10.1093/jpp/rgad091. PMID: 38007392. 5: Srivastava S, Sharma S, Deep S, Khare SK. Screening of Multitarget-Directed Natural Compounds as Drug Candidates for Alzheimer's Disease Using In Silico Techniques: Their Extraction and In Vitro Validation. ACS Omega. 2023 Oct 3;8(41):38118-38129. doi: 10.1021/acsomega.3c04261. PMID: 37867692; PMCID: PMC10586450. 6: Yin Y, Zhao J, Wang P, You S, Zhou Y, Wong JWC, Deng H, Duan G, Zhu Y. Reductive soil disinfestation and Fe amendment improve soil microbial composition and Fritillaria production. Appl Microbiol Biotechnol. 2023 Nov;107(21):6703-6716. doi: 10.1007/s00253-023-12766-z. Epub 2023 Sep 7. PMID: 37676290. 7: Liao H, Quan H, Huang B, Ji H, Zhang T, Chen J, Zhou J. Integrated transcriptomic and metabolomic analysis reveals the molecular basis of tissue- specific accumulation of bioactive steroidal alkaloids in Fritillaria unibracteata. Phytochemistry. 2023 Oct;214:113831. doi: 10.1016/j.phytochem.2023.113831. Epub 2023 Aug 19. PMID: 37598994. 8: Le-Xin C, Ming-Jun L, Chun-Qi X, Jia-Xin Z, Jing-Ya Y, Li-Xin N, Mei-Qi W, En-Xin Z, Xiao-Jun Z. Yi Qi Chu Tan Formula (YQCTF) inhibited the progress of lung cancer via regulating tumor-associated neutrophil: An integrated study of network pharmacology, proteomics and pharmacodynamics. J Ethnopharmacol. 2024 Jan 10;318(Pt B):116943. doi: 10.1016/j.jep.2023.116943. Epub 2023 Aug 1. PMID: 37532072. 9: Peng M, Li J, Zhou J, Zhang B, Liao J, Yang D, Wang Y, Yang Y, Li R, Tang X, Lu Q, Zhao Q. Total alkaloids of Fritillaria unibracteata var. wabuensis bulbus ameliorate chronic asthma via the TRPV1/Ca2+/NFAT pathway. Phytomedicine. 2023 Sep;118:154946. doi: 10.1016/j.phymed.2023.154946. Epub 2023 Jul 2. PMID: 37421766. 10: Hu L, Luo J, Wen G, Sun L, Liu W, Hu H, Li J, Wang L, Su W, Lin L. Identification of the active compounds in the Yi-Fei-San-Jie formula using a comprehensive strategy based on cell extraction/UPLC-MS/MS, network pharmacology, and molecular biology techniques. Phytomedicine. 2023 Jul;115:154843. doi: 10.1016/j.phymed.2023.154843. Epub 2023 Apr 27. PMID: 37149966. 11: Bora PS, Agrawal P, Kaushik NK, Puri S, Sahal D, Sharma U. Antiplasmodial activity of the bulbs of Fritillaria cirrhosa D.Don (Syn: Fritillaria roylei Hook.): UPLC-IM-Q-TOF-MS/MS-based biochemometric approach for the identification of marker compounds. J Ethnopharmacol. 2023 Jun 28;310:116389. doi: 10.1016/j.jep.2023.116389. Epub 2023 Mar 15. PMID: 36924862. 12: Duan Y, Wu J, Wang F, Zhang K, Guo X, Tang T, Mu S, You J, Guo J. Transcriptomic and metabolomic analyses provide new insights into the appropriate harvest period in regenerated bulbs of Fritillaria hupehensis. Front Plant Sci. 2023 Feb 15;14:1132936. doi: 10.3389/fpls.2023.1132936. PMID: 36875619; PMCID: PMC9975545. 13: Zhou A, Li X, Zou J, Wu L, Cheng B, Wang J. Discovery of potential quality markers of Fritillariae thunbergii bulbus in pneumonia by combining UPLC-QTOF- MS, network pharmacology, and molecular docking. Mol Divers. 2024 Apr;28(2):787-804. doi: 10.1007/s11030-023-10620-y. Epub 2023 Feb 26. PMID: 36843054; PMCID: PMC9968501. 14: Liu C, Liu S, Tse WM, Tse KWG, Erbu A, Xiong H, Lanzi G, Liu Y, Ye B. A distinction between Fritillaria Cirrhosa Bulbus and Fritillaria Pallidiflora Bulbus via LC-MS/MS in conjunction with principal component analysis and hierarchical cluster analysis. Sci Rep. 2023 Feb 15;13(1):2735. doi: 10.1038/s41598-023-29631-8. PMID: 36792675; PMCID: PMC9931167. 15: Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ. Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics. Phytomedicine. 2023 Feb;110:154635. doi: 10.1016/j.phymed.2022.154635. Epub 2022 Dec 26. PMID: 36587416. 16: Peng X, Xia Y, Xie J, Liu H, Fan L, Yu C, Ni X. Mechanism of Thunberg Fritillaria in treating endometriosis based on network pharmacology and the effect of Peiminine on the MEK/ERK pathway. Am J Transl Res. 2022 Sep 15;14(9):6196-6209. PMID: 36247281; PMCID: PMC9556459. 17: Lu Q, Li R, Liao J, Hu Y, Gao Y, Wang M, Li J, Zhao Q. Integrative analysis of the steroidal alkaloids distribution and biosynthesis of bulbs Fritillariae Cirrhosae through metabolome and transcriptome analyses. BMC Genomics. 2022 Jul 14;23(1):511. doi: 10.1186/s12864-022-08724-0. PMID: 35836113; PMCID: PMC9284883. 18: Shim KS, Gu DR, Hwang YH, Yang H, Ryuk JA, Ha H. Water Extract of Fritillariae thunbergii Bulbus Inhibits RANKL-Mediated Osteoclastogenesis and Ovariectomy-Induced Trabecular Bone Loss. Molecules. 2021 Dec 28;27(1):169. doi: 10.3390/molecules27010169. PMID: 35011398; PMCID: PMC8746409. 19: Jin X, Gao X, Lan M, Li CN, Sun JM, Zhang H. Study the mechanism of peimisine derivatives on NF-κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide. Chem Biol Drug Des. 2022 May;99(5):717-726. doi: 10.1111/cbdd.14013. Epub 2022 Jan 1. PMID: 34939324. 20: Liu W, Wei L, Kanai Y, He X. Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P-gp. Evid Based Complement Alternat Med. 2021 Oct 5;2021:8351717. doi: 10.1155/2021/8351717. PMID: 34650616; PMCID: PMC8510812.