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MedKoo Cat#: 465447 | Name: SLN-00535

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLN-00535 is a novel SARS-CoV-2 nsp14 Methyltransferase (MTase) inhibitor. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).

Chemical Structure

SLN-00535
SLN-00535
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465447

Name: SLN-00535

CAS#: unknown

Chemical Formula: C26H26N6O5S

Exact Mass: 534.1685

Molecular Weight: 534.59

Elemental Analysis: C, 58.42; H, 4.90; N, 15.72; O, 14.96; S, 6.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SLN-00535; SLN00535; SLN 00535; SARS-CoV-2 nsp14 MTase inhibitor 16;
IUPAC/Chemical Name
S-(((2S,3S,4R,5R)-5-(4-amino-5-(quinolin-3-ylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-L-homocysteine
InChi Key
SPMFBZXXQBXKFX-LUOSIZPJSA-N
InChi Code
InChI=1S/C26H26N6O5S/c27-17(26(35)36)7-8-38-12-19-21(33)22(34)25(37-19)32-11-16(20-23(28)30-13-31-24(20)32)6-5-14-9-15-3-1-2-4-18(15)29-10-14/h1-4,9-11,13,17,19,21-22,25,33-34H,7-8,12,27H2,(H,35,36)(H2,28,30,31)/t17-,19+,21+,22+,25+/m0/s1
SMILES Code
N[C@@H](CCSC[C@H]1O[C@@H](N2C=C(C#CC3=CC4=CC=CC=C4N=C3)C5=C(N)N=CN=C52)[C@H](O)[C@@H]1O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 534.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M. Probing the SAM Binding Site of SARS- CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors. SLAS Discov. 2021 Jul 1:24725552211026261. doi: 10.1177/24725552211026261. Epub ahead of print. PMID: 34192965. 2: Ahmed-Belkacem R, Sutto-Ortiz P, Guiraud M, Canard B, Vasseur JJ, Decroly E, Debart F. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase. Eur J Med Chem. 2020 Sep 1;201:112557. doi: 10.1016/j.ejmech.2020.112557. Epub 2020 Jun 12. PMID: 32563813; PMCID: PMC7291971.