MedKoo Cat#: 414820 | Name: Pefcalcitol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pefcalcitol is a phosphodiesterase inhibitor and is being developed as a topical ointment formulation.

Chemical Structure

Pefcalcitol
Pefcalcitol
CAS#381212-03-9

Theoretical Analysis

MedKoo Cat#: 414820

Name: Pefcalcitol

CAS#: 381212-03-9

Chemical Formula: C26H34F5NO4

Exact Mass: 519.2408

Molecular Weight: 519.55

Elemental Analysis: C, 60.11; H, 6.60; F, 18.28; N, 2.70; O, 12.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Pefcalcitol; M 518101; M518101; M-518101
IUPAC/Chemical Name
Acetamide, 2-((1S)-1-((3aS,7E,7as)-7-((2Z)-((3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene)ethylidene)-3a,4,5,6,7,7a-hexahydro-3a-methyl-1H-inden-3-yl)ethoxy)-N-(2,2,3,3,3-pentafluoropropyl)-
InChi Key
SVCSMAZYWOQCBW-NVJMFHFGSA-N
InChi Code
InChI=1S/C26H34F5NO4/c1-15-18(11-19(33)12-22(15)34)7-6-17-5-4-10-24(3)20(8-9-21(17)24)16(2)36-13-23(35)32-14-25(27,28)26(29,30)31/h6-8,16,19,21-22,33-34H,1,4-5,9-14H2,2-3H3,(H,32,35)/b17-6+,18-7-/t16-,19+,21-,22-,24+/m0/s1
SMILES Code
O=C(NCC(F)(F)C(F)(F)F)CO[C@H](C([C@@]1(C)CCC/2)=CC[C@@]1([H])C2=C\C=C3C([C@@H](O)C[C@H](O)C/3)=C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 519.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Psomadakis CE, Han G. New and Emerging Topical Therapies for Psoriasis and Atopic Dermatitis. J Clin Aesthet Dermatol. 2019 Dec;12(12):28-34. Epub 2019 Dec 1. PMID: 32038762; PMCID: PMC7002051. 2: Takeiri A, Tanaka K, Harada A, Matsuzaki K, Yano M, Motoyama S, Katoh C, Mishima M. Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol. Genes Environ. 2017 Jun 1;39:17. doi: 10.1186/s41021-017-0077-9. PMID: 28580039; PMCID: PMC5452393.