Peforelin | CAS# 147859-97-0 | Gonadotropin-releasing hormone agonist

MedKoo Cat#: 414819 | Name: Peforelin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peforelin is a gonadotropin-releasing hormone agonist medication which is used in veterinary medicine in Europe and Canada. It is a GnRH analogue and a synthetic peptide, specifically a decapeptide.

Chemical Structure

Peforelin

CAS#147859-97-0

Theoretical Analysis

MedKoo Cat#: 414819

Name: Peforelin

CAS#: 147859-97-0

Chemical Formula: C59H74N18O14

Exact Mass: 1258.5632

Molecular Weight: 1259.35

Elemental Analysis: C, 56.27; H, 5.92; N, 20.02; O, 17.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Peforelin

IUPAC/Chemical Name

(3S,6S,9S,12S,15S)-3,12-bis((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-15-(((S)-1-(((S)-6-amino-1-((S)-2-((2-amino-2-oxoethyl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-9-(hydroxymethyl)-1,4,7,10,13-pentaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14-pentaazaheptadecan-17-oic acid

InChi Key

RTASYRSYWSLWJV-CSYZDTNESA-N

InChi Code

InChI=1S/C59H74N18O14/c60-16-6-5-12-40(59(91)77-17-7-13-47(77)58(90)66-27-48(61)79)70-52(84)41(18-31-23-64-37-10-3-1-8-35(31)37)72-56(88)45(22-50(81)82)75-55(87)44(21-34-26-63-30-68-34)74-57(89)46(28-78)76-53(85)42(19-32-24-65-38-11-4-2-9-36(32)38)71-54(86)43(20-33-25-62-29-67-33)73-51(83)39-14-15-49(80)69-39/h1-4,8-11,23-26,29-30,39-47,64-65,78H,5-7,12-22,27-28,60H2,(H2,61,79)(H,62,67)(H,63,68)(H,66,90)(H,69,80)(H,70,84)(H,71,86)(H,72,88)(H,73,83)(H,74,89)(H,75,87)(H,76,85)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1

SMILES Code

NCCCC[C@@H](C(N1CCC[C@H]1C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCC(N2)=O)=O)Cc3nc[nH]c3)=O)Cc(c[nH]4)c5c4cccc5)=O)CO)=O)Cc6nc[nH]c6)=O)CC(O)=O)=O)Cc(c[nH]7)c8c7cccc8)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,259.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: de Jong E, Jourquin J, Kauffold J, Sarrazin S, Dewulf J, Maes D. Effect of a GnRH analogue (peforelin) on the litter performance of gilts and sows. Porcine Health Manag. 2017 Mar 15;3:6. doi: 10.1186/s40813-017-0054-5. PMID: 28405462; PMCID: PMC5382462. 2: Vangroenweghe F, Goossens L, Jourquin J. An evaluation of gonadotropin- releasing hormone analogue administered to gilts and sows on subsequent reproductive performance and piglet birth weight. Porcine Health Manag. 2016 Jan 11;2:1. doi: 10.1186/s40813-016-0018-1. PMID: 28405427; PMCID: PMC5382392. 3: Thomas A, Knoop A, Schänzer W, Thevis M. Characterization of in vitro generated metabolites of selected peptides <2 kDa prohibited in sports. Drug Test Anal. 2017 Nov;9(11-12):1799-1803. doi: 10.1002/dta.2306. Epub 2017 Nov 13. PMID: 28941172. 4: de Jong E, Kauffold J, Engl S, Jourquin J, Maes D. Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows. Theriogenology. 2013 Nov;80(8):870-7. doi: 10.1016/j.theriogenology.2013.07.012. Epub 2013 Aug 27. PMID: 23987986. 5: Brüssow KP, Schneider F, Tuchscherer A, Kanitz W. Influence of synthetic lamprey GnRH-III on gonadotropin release and steroid hormone levels in gilts. Theriogenology. 2010 Dec;74(9):1570-8. doi: 10.1016/j.theriogenology.2010.06.027. Epub 2010 Aug 12. PMID: 20708243.