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MedKoo Cat#: 577314 | Name: Metofenazate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metofenazate is a Calmodulin antagonist.

Chemical Structure

Metofenazate
Metofenazate
CAS#388-51-2

Theoretical Analysis

MedKoo Cat#: 577314

Name: Metofenazate

CAS#: 388-51-2

Chemical Formula: C31H36ClN3O5S

Exact Mass: 597.2064

Molecular Weight: 598.16

Elemental Analysis: C, 62.25; H, 6.07; Cl, 5.93; N, 7.03; O, 13.37; S, 5.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methophenazine; Metofenazate
IUPAC/Chemical Name
Benzoic acid, 3,4,5-trimethoxy-, 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester
InChi Key
BAQLUVXNKOTTHU-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H36ClN3O5S/c1-37-26-19-22(20-27(38-2)30(26)39-3)31(36)40-18-17-34-15-13-33(14-16-34)11-6-12-35-24-7-4-5-8-28(24)41-29-10-9-23(32)21-25(29)35/h4-5,7-10,19-21H,6,11-18H2,1-3H3
SMILES Code
COc1cc(cc(OC)c1OC)C(=O)OCCN2CCN(CCCN3c4ccccc4Sc5ccc(Cl)cc35)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 598.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MY, Quast U, Herzig JW. Metofenazate as a more selective calmodulin inhibitor than trifluoperazine. Arzneimittelforschung. 1987 Sep;37(9):1013-7. PMID: 2449225. 2. Bergstrand H, Eriksson T, Hallberg A, Johansson B, Karabelas K, Michelsen P, Nybom A. Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. J Pharmacol Exp Ther. 1992 Dec;263(3):1334-46. PMID: 1281879. 3. Bergstrand H, Lundquist B. Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. Allergy. 1992 Aug;47(4 Pt 2):353-61. doi: 10.1111/j.1398-9995.1992.tb02071.x. PMID: 1280915.