PD 144795 | CAS# 148550-96-3 | kinase inhibitor

MedKoo Cat#: 414809 | Name: PD 144795

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 144795 inhibited neutrophil adhesion to tumour necrosis factor-α (TNF-α)-activated human umbilical vein endothelial cells

Chemical Structure

PD 144795

CAS#148550-96-3

Theoretical Analysis

MedKoo Cat#: 414809

Name: PD 144795

CAS#: 148550-96-3

Chemical Formula: C13H15NO4S

Exact Mass: 281.0722

Molecular Weight: 281.33

Elemental Analysis: C, 55.50; H, 5.37; N, 4.98; O, 22.75; S, 11.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PD 144795; PD144795; PD-144795

IUPAC/Chemical Name

Benzo(b)thiophene-2-carboxamide, 5-methoxy-3-(1-methylethoxy)-, 1-oxide

InChi Key

VCBBOEAKKOXRTJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H15NO4S/c1-7(2)18-11-9-6-8(17-3)4-5-10(9)19(16)12(11)13(14)15/h4-7H,1-3H3,(H2,14,15)

SMILES Code

O=C(C1=C(OC(C)C)C2=CC(OC)=CC=C2S1=O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 281.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Boschelli DH, Kramer JB, Khatana SS, Sorenson RJ, Connor DT, Ferin MA, Wright CD, Lesch ME, Imre K, Okonkwo GC, et al. Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent. J Med Chem. 1995 Oct 27;38(22):4597-614. doi: 10.1021/jm00022a026. PMID: 7473588. 2: Gualberto A, Marquez G, Carballo M, Youngblood GL, Hunt SW 3rd, Baldwin AS, Sobrino F. p53 transactivation of the HIV-1 long terminal repeat is blocked by PD 144795, a calcineurin-inhibitor with anti-HIV properties. J Biol Chem. 1998 Mar 20;273(12):7088-93. doi: 10.1074/jbc.273.12.7088. PMID: 9507019. 3: Wölle J, Ferguson E, Keshava C, Devall LJ, Boschelli DH, Newton RS, Saxena U. Inhibition of tumor necrosis factor induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo[b]thiophene-2-carboxamide. Biochem Biophys Res Commun. 1995 Sep 5;214(1):6-10. doi: 10.1006/bbrc.1995.2249. PMID: 7545397. 4: Butera ST, Roberts BD, Critchfield JW, Fang G, McQuade T, Gracheck SJ, Folks TM. Compounds that target novel cellular components involved in HIV-1 transcription. Mol Med. 1995 Nov;1(7):758-67. PMID: 8612198; PMCID: PMC2230009. 5: Carballo M, Conde M, Tejedo J, Gualberto A, Jimenez J, Monteseirín J, Santa María C, Bedoya FJ, Hunt SW 3rd, Pintado E, Baldwin AS Jr, Sobrino F. Macrophage inducible nitric oxide synthase gene expression is blocked by a benzothiophene derivative with anti-HIV properties. Mol Genet Metab. 2002 Apr;75(4):360-8. doi: 10.1016/S1096-7192(02)00001-X. PMID: 12051968.